Cas 35333-31-4,8-(4-BROMOPHENYL)-8-OXOOCTANOIC ACID

35333-31-4

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Basic information

Product Name: 8-(4-BROMOPHENYL)-8-OXOOCTANOIC ACID
Synonyms: 8-(4-BROMOPHENYL)-8-OXOOCTANOIC ACID
CAS NO:35333-31-4
Molecular Formula: C₁₄H₁₇BrO₃
Molecular Weight: 313.19
EINECS: N/A
Product Categories: N/A
Mol File: 35333-31-4.mol

Chemical Properties

Melting Point: N/A
Boiling Point: 464.7°C at 760 mmHg
Flash Point: 234.842°C
Appearance: /
Density: 1.357g/cm³
Vapor Pressure: 0mmHg at 25°C
Refractive Index: 1.548
Storage Temp.: N/A
Solubility: N/A
PKA: 4.76±0.10(Predicted)
CAS DataBase Reference: 8-(4-BROMOPHENYL)-8-OXOOCTANOIC ACID(CAS DataBase Reference)
NIST Chemistry Reference: 8-(4-BROMOPHENYL)-8-OXOOCTANOIC ACID(35333-31-4)
EPA Substance Registry System: 8-(4-BROMOPHENYL)-8-OXOOCTANOIC ACID(35333-31-4)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 35333-31-4(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 35333-31-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,5,3,3 and 3 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 35333-31:
(7*3)+(6*5)+(5*3)+(4*3)+(3*3)+(2*3)+(1*1)=94
94 % 10 = 4
So 35333-31-4 is a valid CAS Registry Number.

InChI:InChI=1/C14H17BrO3/c15-12-9-7-11(8-10-12)13(16)5-3-1-2-4-6-14(17)18/h7-10H,1-6H2,(H,17,18)

35333-31-4Upstream product

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35333-31-4Relevant academic research and scientific papers

(2-Amino-phenyl)-amides of ω-substituted alkanoic acids as new histone deacetylase inhibitors

Vaisburg, Arkadii,Bernstein, Naomy,Frechette, Sylvie,Allan, Martin,Abou-Khalil, Elie,Leit, Silvana,Moradei, Oscar,Bouchain, Giliane,Wang, James,Woo, Soon Hyung,Fournel, Marielle,Yan, Pu T.,Trachy-Bourget, Marie-Claude,Kalita, Ann,Beaulieu, Carole,Li, Zuomei,MacLeod, A. Robert,Besterman, Jeffrey M.,Delorme, Daniel

, p. 283 - 287 (2007/10/03)

A variety of ω-substituted alkanoic acid (2-amino-phenyl)-amides were designed and synthesized. These compounds were shown to inhibit recombinant human histone deacetylases (HDACs) with IC50 values in the low micromolar range and induce hyperacetylation of histones in whole cells. They induced expression of p21WAF1/Cip1 and caused cell-cycle arrest in human cancer cells. Compounds in this class showed efficacy in human tumor xenograft models.

Structurally simple trichostatin A-like straight chain hydroxamates as potent histone deacetylase inhibitors

Woo, Soon Hyung,Frechette, Sylvie,Khalil, Elie Abou,Bouchain, Giliane,Vaisburg, Arkadii,Bernstein, Naomy,Moradei, Oscar,Leit, Silvana,Allan, Martin,Fournel, Marielle,Trachy-Bourget, Marie-Claude,Li, Zuomei,Besterman, Jeffrey M.,Delorme, Daniel

, p. 2877 - 2885 (2007/10/03)

A series of new, structurally simple trichostatin A (TSA)-like straight chain hydroxamates were prepared and evaluated for their ability to inhibit partially purified human histone deacetylase 1 (HDAC-1). Some of these compounds such as 8m, 8n, 12, and 15

Inhibitors of histone deacetylase

-

, (2008/06/13)

The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

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