35336-00-6Relevant academic research and scientific papers
Direct oxidative amidation between N,N-dimethylanilines and anhydrides using metal-organic framework [Cu2(EDB)2(BPY)] as an efficient heterogeneous catalyst
Dang, Giao H.,Nguyen, Thanh D.,Le, Dung T.,Truong, Thanh,Phan, Nam T.S.
, p. 1129 - 1137 (2014)
A crystalline porous metal-organic framework [Cu2(EDB) 2(BPY)] was synthesized and used as a heterogeneous catalyst for the direct oxidative amidation between N,N-dimethylanilines and anhydrides to form tertiary amides as the principal products. The [Cu2(EDB) 2(BPY)] exhibited similar activity as compared to that of [Cu 2(BDC)2(BPY)], [Cu2(BDC)2(DABCO)], MOF-143, and other common homogeneous salt catalysts. The optimal reaction conditions employed were [Cu2(EDB)2(BPY)] (10 % mol), TBHP (2 equiv), pyridine (1 equiv) in CH3CN at 80 °C over 2 h. The Cu2(EDB)2(BPY) could be separated from the reaction mixture by filtration, and could be recovered and reused several times without a significant degradation in catalytic activity and selectivity. Furthermore, generality of the optimal conditions was confirmed by employing various N,N-dimethylaniline and anhydride derivatives. Copyright
Amide bond formation through iron-catalyzed oxidative amidation of tertiary amines with anhydrides
Li, Yuanming,Ma, Lina,Jia, Fan,Li, Zhiping
, p. 5638 - 5646 (2013/07/26)
A general and efficient method for amide bond synthesis has been developed. The method allows for synthesis of tertiary amides from readily available tertiary amines and anhydrides in the presence of FeCl2 as catalyst and tert-butyl hydroperoxide in water (T-Hydro) as oxidant. Mechanistic studies indicated that the in situ-generated α-amino peroxide of tertiary amine and iminium ion act as key intermediates in this oxidative transformation.
