35337-98-5

Usage

Uses

Used in Pharmaceutical Industry:
(13R,14R)-14,19-Dihydro-12,13-dihydroxy-20-norcrotalanan-11,15-dione 4-oxide is used as a potential pharmaceutical candidate for [application reason]. Its unique structure and functional groups may allow for interactions with specific biological targets, making it a promising compound for the development of new drugs.
Used in Chemical Research:
In the field of chemical research, (13R,14R)-14,19-Dihydro-12,13-dihydroxy-20-norcrotalanan-11,15-dione 4-oxide can be used as a starting material for the synthesis of other complex organic compounds. Its unique structure and functional groups may provide new insights into the reactivity and properties of related compounds.
Used in Environmental Applications:
(13R,14R)-14,19-Dihydro-12,13-dihydroxy-20-norcrotalanan-11,15-dione 4-oxide may also find use in environmental applications, such as in the development of biodegradable materials or as a component in the remediation of contaminated sites. Its hydroxyl groups could potentially be involved in binding or sequestering harmful substances.
Used in Material Science:
The unique structure of (13R,14R)-14,19-Dihydro-12,13-dihydroxy-20-norcrotalanan-11,15-dione 4-oxide may also be of interest in the field of material science. Its potential to form hydrogen bonds or interact with other molecules could lead to the development of new materials with specific properties, such as improved strength or enhanced environmental stability.

InChI:InChI=1/C16H23NO7/c1-9-13(18)24-11-5-7-17(22)6-4-10(12(11)17)8-23-14(19)16(3,21)15(9,2)20/h4,9,11-12,20-21H,5-8H2,1-3H3

Upstream product

• 315-22-0 monocrotaline 

Downstream Products

• 315-22-0 monocrotaline 

Relevant academic research and scientific papers

Characteristic ion clusters as determinants for the identification of pyrrolizidine alkaloid N-oxides in pyrrolizidine alkaloid-containing natural products using HPLC-MS analysis

Pyrrolizidine alkaloid (PA)-containing plants are widely distributed in the world. PAs are hepatotoxic, affecting livestock and humans. PA N-oxides are often present together with PAs in plants and also exhibit hepatotoxicity but with less potency. HPLC-MS is generally used to analyze PA-containing herbs, although PA references are unavailable in most cases. However, to date, without reference standards, HPLC-MS methodology cannot distinguish PA N-oxides from PAs because they both produce the same characteristic ions in mass spectra. In the present study, the mass spectra of 10 PA N-oxides and the corresponding PAs were systemically investigated using HPLC-MS to define the characteristic mass fragment ions specific to PAs and PA N-oxides. Mass spectra of toxic retronecine-type PA N-oxides exhibited two characteristic ion clusters at m/z 118-120 and 136-138. These ion clusters were produced by three unique fragmentation pathways of PA N-oxides and were not found in their corresponding PAs. Similarly, the nontoxic platynecine-type PA N-oxides also fragmented via three similar pathways to form two characteristic ion clusters at m/z 120-122 and 138-140. Further application of using these characteristic ion clusters allowed successful and rapid identification of PAs and PA N-oxides in two PA-containing herbal plants. Our results demonstrated, for the first time, that these characteristic ion clusters are unique determinants to discriminate PA N-oxides from PAs even without the availability of reference samples. Our findings provide a novel and specific method to differentiate PA N-oxides from PAs in PA-containing natural products, which is crucial for the assessment of their intoxication.