35341-74-3

Upstream product

• 50-00-0 formaldehyd 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 151-50-8 potassium cyanide 
• 590-17-0 cyanomethyl bromide 

Downstream Products

• 935289-83-1 3,5-dichloro-1-[(1R)-1-phenylethyl]-2(1H)-pyrazinone 
• 1257389-88-0 2-{N-[(R)-1-phenylethyl]-N-[2-methylallyl]amino}acetonitrile 
• 1384290-09-8 ethyl (1R,5R,1'R)-3-(1'-phenylethyl)-6-oxo-3-azabicyclo[3.3.1]nonane-1-carboxylate 
• 1384289-55-7 ethyl (1S,5S,1'R)-3-(1'-phenylethyl)-6-oxo-3-azabicyclo[3.3.1]nonane-1-carboxylate 
• 1384289-52-4 ethyl (R)-2-(((cyanomethyl)(1-phenylethyl)amino)methyl)acrylate 
• 935289-91-1 (1S,4S)-1-methyl-5-[(1R)-1-phenylethyl]-2,5-diazabicyclo[2.2.2]octane-3,6-dione 
• 935289-89-7 5-chloro-3-methyl-1-[(1R)-1-phenylethyl]-2(1H)-pyrazinone 
• 935289-88-6 tert-butyl 3-({ 6-chloro-3-oxo-4-[(1R)-1-phenylethyl]-3,4-dihydro-2-pyrazinyl}methyl)-1H-indole-1-carboxylate 
• 935289-87-5 3-benzyl-5-chloro-1-[(1R)-1-phenylethyl]-2(1H)-pyrazinone 

Relevant academic research and scientific papers

Dynamics in Catalytic Asymmetric Diastereoconvergent (3 + 2) Cycloadditions with Isomerizable Nitrones and α-Keto Ester Enolates

Reaction design in asymmetric catalysis has traditionally been predicated on a structurally robust scaffold in both substrates and catalysts, to reduce the number of possible diastereomeric transition states. Herein, we present the stereochemical dynamics in the Ni(II)-catalyzed diastereoconvergent (3 + 2) cycloadditions of isomerizable nitrile-conjugated nitrones with α-keto ester enolates. Even in the presence of multiple equilibrating species, the catalytic protocol displays a wide substrate scope to access a range of CN-containing building blocks bearing adjacent stereocenters with high enantio- and diastereoselectivities. Our computational investigations suggest that the enantioselectivity is governed in the deprotonation process to form (Z)-Ni-enolates, while the unique syn addition is mainly controlled by weak noncovalent bonding interactions between the nitrone and ligand.

Chiral N-hydroxybenzamides as potential catalysts for aerobic asymmetric oxidations

Chiral N-hydroxybenzamides (1H-3H) have been synthesized as precursors of chiral short-lived N-oxyl radicals 1?-3?. The latter species have been generated by oxidation of 1H-3H with Pb(OAc)4 or hydrogen abstraction from 1H-3H by the tert-butoxyl radical and characterized by UV-vis spectrophotometry and EPR spectroscopy. Through a kinetic study of the hydrogen atom transfer processes promoted by 1?-3? from three chiral benzylic substrates (1-phenylethylamine, 1-phenylethanol, and α-vinylbenzyl alcohol), a moderate chiral discrimination has been found, with selectivity factors 0.5 ≥ kH(S)/kH(R) ≥ 2.

BIS-PYRIDYLPYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS

The invention provides novel bis-pyridylpyridones which are antagonists at the melanin-concentrating hormone receptor 1 (MCHR1 ), pharmaceutical compositions containing them, processes for their preparation, and their use in therapy and for the treatment

Diastereoselective Diels-Alder additions of ethene to substituted homochiral 2(1H)-pyrazinones

Diels-Alder reactions of ethene with 2(1H)-pyrazinones bearing a homochiral auxiliary group are presented. The cycloaddition products form with diasteromeric excesses of up to 50%. To the best of our knowledge, these are the first Diels-Alder reactions wi