353471-56-4

Upstream product

• 126-81-8 dimedone 
• 24313-88-0 3,4,5-Trimethoxyaniline 

Downstream Products

• 1203810-13-2 2-amino-7,7-dimethyl-4-(thienyl-2-yl)-5-oxo-1-(3,4,5-trimethoxyphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1203810-12-1 2-amino-7,7-dimethyl-4-(5-methyl-furan-2-yl)-5-oxo-1-(3,4,5-trimethoxyphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1203810-10-9 2-amino-7,7-dimethyl-4-(2-methoxy-1-naphthyl)-5-oxo-1-(3,4,5-trimethoxyphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1203810-11-0 2-amino-7,7-dimethyl-4-(4-methoxy-1-naphthyl)-5-oxo-1-(3,4,5-trimethoxyphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1203810-02-9 2-amino-7,7-dimethyl-4-(benzo[d][1,3]dioxol-5-yl)-5-oxo-1-(3,4,5-trimethoxyphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1203810-01-8 2-amino-7,7-dimethyl-4-(2-chlorophenyl)-5-oxo-1-(3,4,5-trimethoxyphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1203810-00-7 2-amino-7,7-dimethyl-4-(4-methoxyphenyl)-5-oxo-1-(3,4,5-trimethoxyphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1203809-94-2 2-amino-7,7-dimethyl-5-oxo-4-phenyl-1-(3,4,5-trimethoxyphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1203809-95-3 2-amino-7,7-dimethyl-5-oxo-4-(4-tolyl)-1-(3,4,5-trimethoxyphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1203810-04-1 2-amino-7,7-dimethyl-4-(4-nitrophenyl)-5-oxo-1-(3,4,5-trimethoxyphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1203810-08-5 2-amino-7,7-dimethyl-4-(2,4,5-trimethoxyphenyl)-5-oxo-1-(3,4,5-trimethoxyphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1203810-03-0 2-amino-7,7-dimethyl-4-(3-nitrophenyl)-5-oxo-1-(3,4,5-trimethoxyphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1203809-98-6 2-amino-7,7-dimethyl-5-oxo-4-styryl-1-(3,4,5-trimethoxyphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1203810-07-4 2-amino-7,7-dimethyl-4-(3-ethoxy-4-methoxy-1-phenyl)-5-oxo-1-(3,4,5-trimethoxyphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 

Relevant academic research and scientific papers

Synthesis and biological evaluation of 2-amino-7,7-dimethyl 4-substituted-5-oxo-1-(3,4,5-trimethoxy)-1,4,5,6,7,8-hexahydro-quinoline-3-carbonitrile derivatives as potential cytotoxic agents

A large number of antimitotic drugs, derived from natural sources or chemically synthesized, have been identified and shown to interfere with the tubulin system. Inhibition of tubulin polymerization is among the important targets useful in the cancer ther

Synthesis, crystal structure and effect of indeno[1,2-b]indole derivatives on prostate cancer in vitro. Potential effect against MMP-9

A highly regiospecific synthesis of a series of indenoindoles is reported, together with X-ray studies and their activity against human prostate cancer cells PC-3 and LNCaP in vitro. The most effective compound 7,7-dimethyl-5-[(3,4-dichlorophenyl)]-(4bRS,9bRS)-dihydroxy-4b,5,6,7,8,9bhexahydro-indeno[1,2-b]indole-9,10-dione 7q reduced the viability in both cell lines in a time and dose-dependent manner. Inhibitory effects were also observed on the adhesion, migration, and invasion of the prostate cancer cells as well as on clonogenic possibly by inhibition of MMP-9 activity. Molecular docking of 7q and 6k into MMP-9 human active site was also performed to determine the probable binding mode.

Synthesis, crystal structure and anti-breast cancer activity of some enaminone derivatives

The present work reports the synthesis of some enaminone derivatives bearing a biologically active 3,4-dimethoxyphenyl (3) or 3,4,5-trimethoxyphenyl moieties (5 and 7), respectively. The trimethoxybenzene moiety has been previously reported to confer cyto