3535-04-4Relevant articles and documents
Thermodynamically Controlled 1,3-Asymmetric Induction in an Acyclic System: Equilibration of α-Amino Nitriles Derived from α-Alkylbenzylamines and Aldehydes
Inaba, Takashi,Fujita, Makoto,Ogura, Katsuyuki
, p. 1274 - 1279 (2007/10/02)
Acyclic α-amino nitriles 1, derived from α-alkylbenzylamines 3 and aldehydes 4 via a Strecker-type reaction, readily epimerize in MeOH at the newly emerged asymmetric center α to the cyano group.The equilibrium diastereomeric ratio :