3535-32-8

Usage

Uses

3-Methoxy-4-propoxybenzoic acid

InChI:InChI=1/C11H14O4/c1-3-6-15-9-5-4-8(11(12)13)7-10(9)14-2/h4-5,7H,3,6H2,1-2H3,(H,12,13)/p-1

Upstream product

• 29653-04-1 4-allyl-2-methoxy-1-propoxy-benzene 
• 121-34-6 3-methoxy-4-hydroxybenzoic acid 
• 106-94-5 propyl bromide 
• 3535-26-0 methyl 3-methoxy-4-propoxybenzoate 
• 3943-74-6 4-hydroxy-3-methoxybenzoic acid methyl ester 
• 57695-98-4 3-methoxy-4-n-propoxybenzaldehyde 

Downstream Products

• 3535-38-4 4-n-propoxy-3-methoxybenzoil chloride 
• 90-05-1 2-methoxy-phenol 
• 29515-39-7 1-methoxy-2-n-propoxybenzene 

Relevant academic research and scientific papers

VU6010608, a Novel mGlu7 NAM from a Series of N-(2-(1H-1,2,4-Triazol-1-yl)-5-(trifluoromethoxy)phenyl)benzamides

Herein, we report the structure-activity relationships within a series of mGlu7 NAMs based on an N-(2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)benzamide core with excellent CNS penetration (Kp 1.9-5.8 and Kp,uu 0.4-1.4). Analogues in this series displayed steep SAR. Of these, VU6010608 (11a) emerged with robust efficacy in blocking high frequency stimulated long-term potentiation in electrophysiology studies.

Synthesis and thermal properties of cholesteryl 4-n-alkoxy-3-methoxybenzoates

A homologous series of new liquid crystalline compounds, cholesteryl 4-n-alkoxy-3-methoxybenzoate were synthesized from vanillin and their mesomorphic properties were studied by differential scanning calorimetry, polarizing microscopy and x-ray diffractometry.Each of the homologues from cholesteryl 3,4-dimethoxybenzoate (n=1) to cholesteryl 4-n-hexyloxy-3-methoxybenzoate (n=6) showed a cholesteric-nematic phase (NCh).The other higher homologues (from n=7 to n=18) indicated smectic A (SA) and NCh phases.The temperature region of smectic phases increased with the increase of the chain length of the n-alkoxy group.Transition temperatures in each of the homologues were lower than those in a corresponding non-3-methoxy substituted benzoate ester, due to the destabilizing effect of the lateral methoxy group.The effect was more significant on the homologues having a shorter n-alkoxy chain.It was also found that these esters formed a glassy state by quenching from mesophases and/or the isotropic liquid phase.The change of the glass transition temperature on each homologue (from n=1 to n=6) suggested the effect of the chain length of the n-alkoxyl group on the formation of the glassy state.Keywords: liquid crystals, thermal properties, differential scanning calorimetry, cholesteric phas, smectic A phase, glassy phase.