3535-39-5Relevant articles and documents
Novel domino synthesis of 2-(2,3.4-substituted phenyl) quinazolin-4-amine
Ali, Ibrahim A. I.,El Rayes, Samir M.,Fathalla, Walid,Khalifa, Mohamed E.,Pazdera, Pavel
, (2022/01/13)
Convenient domino protocol was developed for the synthesis of 2-arylquinazolin-4-amines by the reaction of N-(2-cyanophenyl) substituted benzimidoyl isothiocyanates with isopropyl amine. The major advantages of this protocol are short reaction times, mild conditions, simple work up, high yields, and pure products. The efficacy of this protocol owes to the competence of synthesis, pure isolation of imidoyl isothiocyanates, and the unique structure conformation of the corresponding intermediate thiourea derivatives.
PYRAN-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS
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, (2013/07/31)
The invention relates to pyran spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the composition