3535-39-5

Upstream product

• 121-34-6 3-methoxy-4-hydroxybenzoic acid 
• 138505-27-8 4-bromo-1-isopropoxy-2-methoxy-benzene 
• 7368-78-7 4-bromoguaiacol 
• 3535-33-9 4-isopropyloxy-3-methoxybenzoic acid 

Downstream Products

• 26994-48-9 6β-(4-isopropoxy-3-methoxy-benzoylamino)-penicillanic acid 
• 1448520-17-9 3-(4-isopropoxy-3-methoxybenzoyl)-11-oxa-3-azaspiro[5.5]undec-9-en-8-one 
• 1448520-18-0 3-(4-isopropoxy-3-methoxybenzoyl)-10-phenyl-11-oxa-3-azaspiro[5.5]undec-9-en-8-one 
• 1448520-12-4 1-(4-isopropoxy-3-methoxybenzoyl)piperidin-4-one 
• 1392291-33-6 (4-isopropoxy-3-methoxyphenyl)(2'-methyl-6'-(trifluoromethyl)-3',4'-dihydro-2'H-spiro[piperidine-4,1'-pyrrolo[1,2-a]pyrazine]-1-yl)methanone 

Relevant academic research and scientific papers

Novel domino synthesis of 2-(2,3.4-substituted phenyl) quinazolin-4-amine

Convenient domino protocol was developed for the synthesis of 2-arylquinazolin-4-amines by the reaction of N-(2-cyanophenyl) substituted benzimidoyl isothiocyanates with isopropyl amine. The major advantages of this protocol are short reaction times, mild conditions, simple work up, high yields, and pure products. The efficacy of this protocol owes to the competence of synthesis, pure isolation of imidoyl isothiocyanates, and the unique structure conformation of the corresponding intermediate thiourea derivatives.

SOLID FORMS OF (4-ISOPROPOXY-3-METHOXYPHENYL)(2'-METHYL-6'-(TRIFLUOROMETHYL)-3',4'-DIHYDRO-2'H-SPIRO[PIPERIDINE-4,1'-PYRROLO[1,2-A]PYRAZINE]-1-YL)METHANONE

The invention relates to solid state forms, for example, crystalline forms, of (4-isopropoxy-3-methoxyphenyl)(2'-methyl-6'-(trifluoromethyl)-3,,4'- dihydro-2'H-spiro[piperidine-4, 1 '-pyrrolo[ 1,2-a]pyrazine]- 1 -yl)methanone (Compound 1) or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods therewith. The present invention also relates to a method of preparing Compound 1 in various solid forms. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders such as pain.

PYRAN-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS

The invention relates to pyran spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the composition