35352-91-1Relevant academic research and scientific papers
Three-Dimensional Porous Architectures Based on MnII/III Three-Blade Paddle Wheel Metallacryptates
Marzaroli, Vittoria,Spigolon, Giulia,Lococciolo, Giuseppe,Quaretti, Martina,Salviati, Clarissa,Kampf, Jeff W.,Licini, Giulia,Marchiò, Luciano,Pecoraro, Vincent L.,Tegoni, Matteo
, p. 1954 - 1964 (2019/03/02)
Three metallacryptate supramolecular assemblies have been obtained using salicylhydroxamic acid derivatives (H3L). The three ligands differ in the residue at the para position with respect to the hydroxamic function (-H, -NH2, and -(
Synthesis of hydroxy- and amino-substituted benzohydroxamic acids: Inhibition of ribonucleotide reductase and antitumor activity
van't Riet,Wampler,Elford
, p. 589 - 592 (2007/10/05)
Benzohydroxamic acids inhibit mammalian ribonucleotide reductase and exhibit antineoplastic activity in L1210 leukemic mice. Five new hydroxy- and amino-substituted benzohydroxamic acids (3,4- and 3,5-OH,3,4-NH2, 2,3,4-, and 3,4,5-OH) were prepared and tested along with 12 previously reported benzohydroxamic acids (BHA) for enzyme inhibition and antitumor activity. The most potent enzyme inhibitor in this series was 2,3,4-OH-BHA (ID50=3.5 μM), which is 140 times more potent than hydroxyurea, but its toxicity limited the antitumor activity to a 30% increase in life span of L1210 bearing mice at 125 (mg/kg) day ip for 8 days. The most effective antitumor agent in this series was 3,4-OH-BHA which prolonged the life span of L1210 bearing mice 103% at 600 (mg/kg)/day ip for 8 days.
