35357-99-4Relevant academic research and scientific papers
Zinc-catalyzed aminolysis of epoxides
Pachón, Laura Durán,Gamez, Patrick,Van Brussel, Jos J. M.,Reedijk, Jan
, p. 6025 - 6027 (2003)
A series of amino alcohols has been prepared by a novel zinc-catalyzed nucleophilic opening of epoxide rings by amines.
Microwave-enhanced bismuth triflate-catalyzed epoxide opening with aliphatic amines
Ollevier, Thierry,Nadeau, Etienne
, p. 1546 - 1550 (2008/09/19)
In the presence of a catalytic amount of Bi(OTf)3·4H2O and under microwave irradiation, neat mixtures of epoxides and amines afforded smoothly the corresponding 2-amino alcohols. A wide variety of aliphatic amines were reacted with cycloalkene oxide, styrene oxide, and stilbene oxide. The reaction proceeded rapidly and afforded the 2-amino alcohols in high up to quantitative yields. All products could be obtained without aqueous work-up by simple filtration.
