35359-26-3

Usage

Chemical structure

1,5-dimethyl[1,2,4]triazolo[4,3-a]quinoline is a heterocyclic compound with a complex structure that includes a triazolo and quinoline ring.

Heterocyclic compound

It is a compound containing one or more rings of atoms with at least one atom in the ring being a heteroatom, which is an atom other than carbon.

Two methyl groups

The compound has two methyl groups attached to the 1 and 5 positions of the triazolo ring.

Potential applications

It has potential applications in the field of medicinal chemistry.

Drug candidate

Due to its structural features and potential biological activities, it may serve as a potential drug candidate.

Further research needed

More research is required to fully understand its properties and potential uses.

Structural features

The compound's structure may contribute to its potential biological activities and medicinal applications.

Biological activities

The compound may exhibit biological activities that could be useful in the development of new drugs or therapies.

Upstream product

• 21703-52-6 2-hydrazinyl-4-methylquinoline 
• 79-24-3 Nitroethane 

Relevant academic research and scientific papers

Nitroalkanes as electrophiles: Synthesis of triazole-fused heterocycles with neuroblastoma differentiation activity

We discovered a reaction of nitroalkanes with 2-hydrazinylquinolines, 2-hydrazinylpyridines and bis-2,4-dihydrazinylpyrimidines in polyphosphoric acid (PPA) affording 1,2,4-triazolo[4,3-a]quinolines, 1,2,4-triazolo[4,3-a]pyridines and bis[1,2,4]triazolo[4,3-a:4′,3′-c]pyrimidines, respectively. The reaction expands the scope of heterocyclic annulations involving phosphorylated nitronates, believed to be the electrophilic intermediates formed from nitroalkanes in PPA. Several of the synthesized triazoles showed promising anticancer activity by inducing differentiation in neuroblastoma cancer cells. Due to the urgent need for novel differentiation agents for neuroblastoma therapy, this finding warrants further evaluation of this class of compounds against neuroblastoma.

Microwave assisted synthesis and antifungal activity of 1,2,4-triazine, 1,2,4-triazole, tetrazole and pyrazole derivatives

The condensation reactions of 2-hydrazino-4-methylquinoline with diethyl oxalate, ethyl bromoacetate, aromatic aldehydes, acetic anhydride, nitrous acid and different acetophenones followed by DMF and POCl3 under microwave irradiation and by conventional methods are described. The reaction rate is enhanced tremendously under microwave irradiation as compared to conventional method with improved yields. All the newly synthesised compounds have been screened for antifungal activity against fungi A. niger andA.flavous.

Agent for the control of plant-pathogenic organisms

Methods employing and compositions comprising, for the control of plant-pathogenic organisms, specified s-triazolo(4,3-a)quinoline compounds, some of which are claimed as novel compounds.