353751-75-4Relevant academic research and scientific papers
Stereoselective synthesis of the pyrroloisoquinoline ring system
Allin, Steven M,James, Stella L.,Martin, William P.,Smith, Timothy A.D.
, p. 3943 - 3946 (2001)
We report a novel, facile and stereoselective approach to the pyrroloisoquinoline ring system from readily available, non-racemic, bicyclic lactam substrates.
Stereoselective synthesis of the pyrroloisoquinoline ring system
Allin, Steven M.,James, Stella L.,Martin, William P.,Smith, Timothy A.D.,Elsegood, Mark R.J.
, p. 3029 - 3036 (2007/10/03)
In this paper we report a facile and stereoselective approach to the pyrroloisoquinoline ring system through the application of N-acyliminium chemistry from readily available non-racemic chiral templates. The stereochemical outcome of the cyclisation reactions has been determined by NOE and X-ray crystallography. We also demonstrate the synthetic potential of our new approach through removal of the pendant hydroxymethyl auxiliary from a product of cyclisation.
