35388-47-7

Upstream product

• 1932-03-2 2-(piperidin-4-yl)ethyl chloride 
• 140-29-4 phenylacetonitrile 
• 2008-75-5 N-chloroethylpiperidine hydrochloride 
• 4553-07-5 ethyl phenylcyanoacetate 
• 17877-17-7 1-((trimethylsilyl)methyl)piperidine 
• 591-50-4 iodobenzene 
• 107-13-1 acrylonitrile 
• 110-89-4 piperidine 
• 93273-13-3 4-chloro-2-phenylbutyronitrile 

Downstream Products

• 56951-07-6 1-(4-chlorophenyl)-4-[2-(1-piperidino)-ethyl]-1,4-dihydro-2H-isoquinoline-3-one 
• 112821-46-2 2-Phenyl-2-(1-piperidylethyl)-glutaronitril 
• 629165-67-9 2-phenyl-4-piperidino-butyric acid amide 
• 109693-11-0 ethyl 2-phenyl-4-(piperidin-1-yl)butanoate 
• 405071-96-7 rac-2-cyclopentyl-2-phenyl-4-(piperidin-1-yl)-butyronitrile 
• 629165-66-8 2-cyclohexyl-2-phenyl-4-piperidino-butyronitrile 
• 875229-32-6 2-cyclohexyl-2-phenyl-4-piperidino-butyric acid amide 

Relevant academic research and scientific papers

Selective 1,2-Aryl-Aminoalkylation of Alkenes Enabled by Metallaphotoredox Catalysis

A highly chemo- and regioselective intermolecular 1,2-aryl-aminoalkylation of alkenes by photoredox/nickel dual catalysis is described here. This three-component conjunctive cross-coupling is highlighted by its first application of primary alkyl radicals, which were not compatible in previous reports. The readily prepared α-silyl amines could be transferred to α-amino radicals by photo-induced single electron transfer step. The radical addition/cross-coupling cascade reaction proceeds under mild, base-free and redox-neutral conditions with good functional group tolerance, and importantly, provides an efficient and concise method for the synthesis of structurally valuable α-aryl substituted γ-amino acid derivatives motifs.

Preparation method of 2-aryl-gamma-aminobutyric acid derivative

The invention belongs to the field of organic synthesis, and particularly discloses a preparation method of a 2-aryl-gamma-aminobutyric acid derivative. The method comprises the following steps: by taking alpha-aminomethyl silicon, aryl (or heteroaryl) halide and olefin as substrates, adding catalytic amounts of a photocatalyst and a transition metal catalyst, a ligand and a proper amount of a solvent, reacting at room temperature under the protection of protective gas and blue light irradiation, and separating and purifying to obtain the 2-aryl-gamma-aminobutyric acid derivative. The method has the advantages of simple operation, cheap and easily available raw materials, mild reaction conditions, and realization of synthesis of complex drug active molecules through one-step reaction, andcan be used for rapid construction of a compound library containing the skeleton of the drug active molecules.