3540-94-1Relevant academic research and scientific papers
Synthesis of N1-substituted benzamidines. Effects on blood coagulation, platelet aggregation and antiarrhythmic activity.
Ferroni,Simoni,Manfredini,Guarneri,Orlandini,Barbieri,Franze,Mugelli
, p. 665 - 669 (2007/10/02)
A series of N1-substituted-4-alkoxybenzamidines was synthesized and tested in vitro for their inhibitory effects on blood coagulation and agonist induced platelet aggregation. The antiarrhythmic activity against chloroform-induced arrhythmias in mice was also evaluated. The biological activity of the title compounds is reported in comparison with that of procainamide; among the new products described, IVi and IVe were found to have the most potent anti-platelet and antiarrhythmic activity, respectively. The structure-activity relationships are discussed.
Anti-arythmiques apparentes au procainamide II. Synthese et etude pharmacologique
Reynaud, Pierre,Brion, Jean-Daniel,Nguyen-Tri-Xuong, Emmanuel,Davrinche, Catherine,Pieri, Francois,Arnold-Guerin, Marie-Luce
, p. 427 - 434 (2007/10/02)
Anti-arrhythmic agents related to procainamide II.Synthesis and pharmacological study.In view of their marked anti-arrhythmic activity, we continued our studies on the N--4-alkoxy-benzamidines described previously.We prepared p
