Poison by ingestion. Moderately toxic by skin contact. When heated to decomposition it emits very toxic fumes of POx and SOx.
A potential danger to those involved in the manufacture, formulation, and application of this insecticide that is used for control of certain lepidopterous, dipterous, and hemipterous insects on cotton, etc.
oral LD50 for rats is 176–304 mg/kg. Inhalation LC50
(4 h) for rats is >4.1 mg/L air. NOEL (2 yr) for rats is
6 mg/kg diet (0.3 mg/kg/d). ADI is 3 μg/kg b.w. Sulprofos
administered to rats is rapidly metabolized, and 92% of
the dose is excreted within 24 h.
Sulprofos is a tan colored liquid.
Tan colored liquid; sulfide odor. Soluble in organic solvents; insoluble in water.
In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.
UN3018 Organophosphorus pesticides, liquid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Strong oxidizers may cause release of toxic phosphorus oxides. Organophosphates, in the presence of strong reducing agents such as hydrides, may form highly toxic and flammable phosphine gas. Keep away from alkaline materials.
Major metabolic routes
are by oxidation to the sulfoxide and sulfone and oxidative
desulfuration to the oxons. Detoxification by dearylation
to the phenols occurs rapidly. Sulprofos is degraded in soil
with a half-life ranging from a few days to several weeks,
depending on the soil type.
Tan-colored liquid with a sulfide-like odor.
The half-lives in aqueous solution at pH values 4,7 and 9 were 26,151 and
51 days, respectively. Its DT50 was less than two days when a thin film
was exposed to sunlight. Ivie and Bull (1976), examined the photodecomposition
in sunlight of sulprofos on cotton leaves, glass surfaces
and aqueous solutions. The major metabolites were sulprofos sulfoxide
(2) and sulfone (3), with minor amounts of sulprofos oxon sulfoxide (4)
and the three possible phenolic hydrolysis products (5, 6 and 7). Photodecomposition
is thus via thiooxidation, oxidative desulfuration and
cleavage of the P-O-aryl group as shown in Scheme 1. A large number of
minor photolysis products which could not be identified were also
Organothiophosphates are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
Sulprofos is used to control Lepidoptera, thrips and other insects in
cotton, soya, tobacco, vegetables and tomatoes.
Biological. From the first-order biotic and abiotic rate constants of sulprofos in estu-
arine water and sediment/water systems, the estimated biodegradation half-lives were
19.5–61.6 and 3.5–19 days, respectively (Walker et al., 1988).Photolytic. When sulprofos was exposed to sunlight as deposits on cotton foliage, glass
surfaces and in aqueous solution, the insecticide degraded rapidly (half-life <2 days).
Irradiation of sulprofos in aqueous solution using UV light (λ >290Chemical/Physical. Emits toxic oxides of sulfur and phosphorus when heated to
decomposition (Lewis, 1990).
Cholinesterase inhibitor. Questionable carcinogen.
Sulprofos is an organophosphorus insecticide possessing a 4-(methylthio)
phenyl group and as such its metabolic fate has much in common
with fenthion with which it also has the phosphorothioate (P=S) group in
common. The major route of sulprofos metabolism is by oxidation to the
sulfoxide and more slowly to the sulfone. The additional route of bioactivation
is through oxidative desulfuration to form the sulprofos oxon
and all five oxidative metabolites (sulprofos sulfoxide, sulprofos sulfone,
sulprofos oxon, sulprofos oxon sulfoxide and sulprofos oxon sulfone)
have been detected in rats. Degradative metabolism by hydrolysis or oxidative
dearylation to the phenols occurs rapidly. Stage II metabolism in
mammals involves the rapid conjugation of the phenolic dearylation
products. The fate of the S-propyl phosphorodithioate group has not
apparently been reported.