35402-70-1Relevant academic research and scientific papers
Iron-catalyzed C(sp3)-H functionalization of: N, N -dimethylanilines with isocyanides
Guerrero, Itziar,San Segundo, Marcos,Correa, Arkaitz
, p. 1627 - 1630 (2018)
An efficient ligand-free Fe-catalyzed oxidative Ugi-type reaction toward the assembly of α-amino amides and short peptides is described. The reaction proceeds through the α-C(sp3)-H oxidation of N,N-dimethylanilines and further nucleophilic attack of the resulting iminium species by isocyanides. Additive screening showed that judicious choice of the carboxylic acid could lead to the formation of α-amino imides via a 3-component reaction. The process occurs with operational simplicity and is compatible with a variety of sensitive functional groups.
The Dark Side of Isocyanides: Visible-Light Photocatalytic Activity in the Oxidative Functionalization of C(sp3)–H Bonds
Russo, Camilla,Amato, Jussara,Tron, Gian Cesare,Giustiniano, Mariateresa
, p. 18117 - 18127 (2021/12/13)
The possibility to harness aromatic isocyanides as visible-light photocatalysts in the α-amino C(sp3)–H functionalization is herein presented. Actually, the three-component cross-dehydrogenative coupling of aromatic tertiary amines with isocyan
