35409-82-6Relevant academic research and scientific papers
Chiral azo compounds: Enantioselective synthesis and transformations into β-amino alcohols and α-amino acids with a quaternary stereocenter
Dietz, Friedrich R.,Prechter, Agnes,Gr?ger, Harald,Heinrich, Markus R.
supporting information; experimental part, p. 655 - 657 (2011/03/21)
Taking advantage of radical carboaminations producing azo compounds, a new chemo-enzymatic approach to enantiomerically enriched azo alcohols, β-amino alcohols and non-natural (aromatic) amino acids with a quaternary stereocenter is reported.
Highly diastereoselective addition of Grignard reagents to aliphatic, enolizable N-alkylketimines and 2,2-disubstituted 1,3-oxazolidines. Asymmetric synthesis of the antidepressant cericlamine
Steinig,Spero
, p. 2406 - 2410 (2007/10/03)
Grignard reagents were added to 2,2-disubstituted 1,3-oxazolidines and enolizable ketimines prepared from hydroxyacetone and phenylglycinol derivatives, with high to excellent diastereoselectivity, to yield 2,2- disubstituted 1,2-amino alcohol derivatives. Lewis acids had considerable influence on the yield and diastereoselectivity of the addition. This method was applied to the first asymmetric synthesis of the 5-HT reuptake inhibitor Cericlamine.
On the Origin of Asymmetric Induction of the Palladium-Catalyzed Allylic Substitution Reaction with Chiral 4,4-Disubstituted 4,5-Dihydro-2-(phosphinoaryl)oxazole Ligands
Schaffner, Silvia,Mu?ller, Ju?rgen F. K.,Neuburger, Markus,Zehnder, Margarets
, p. 1223 - 1232 (2007/10/03)
The X-ray analyses of (η 3-allyl){4-benzyl-2-[2-(diphenylphosphino-κP)phenyl]-4,5- dihydro-4-methyloxazole-κN}palladium(II) hexafluorophosphate (5) and the analogous [Pd(η3-1,3-diphenylallyl)] complex 6 are presented. A comparison wi
