3541-40-0Relevant academic research and scientific papers
A Bioinspired Cascade Sequence Enables Facile Assembly of Methanodibenzo[b,f][1,5]dioxocin Flavonoid Scaffold
Liu, Hongxin,Wang, Yu,Guo, Xueying,Huo, Luqiong,Xu, Zhifang,Zhang, Weimin,Qiu, Shengxiang,Yang, Bao,Tan, Haibo
, p. 546 - 549 (2018)
A remarkable bioinspired EDDA-mediated method for the selective construction of biologically interesting and highly strained bridged methanodibenzo[b,f][1,5]dioxocin flavonoid scaffold was uncovered by starting from a variety of readily available acylphloroglucinol and 2-hydroxycinnamaldehyde substrates. This method merges a fascinating olefin isomerization/hemiacetallization/dehydration/[3 + 3]-type cycloaddition cascade reaction driven by an in situ generated chromenylium intermediate and provides a convenient and viable synthetic strategy for the efficient access of such flavonoid analogues.
