35410-28-7Relevant articles and documents
Synthesis of novel anti-inflammatory steroidal macrocycles using ring closing metathesis reaction
Biju, Purakkattle,Bitar, Rema,Lim, Yeon-Hee,Wang, Ying,Berlin, Michael,Aslanian, Robert,McCormick, Kevin
, p. 636 - 638 (2015)
A novel class of 13 and 16 membered steroidal macrocycles were synthesized by using ring closing metathesis reaction from the readily available anti-inflammatory steroids such as prednisolone, 6-methyl prednisolone, and 16-methyl prednisolone.
Steroidal C-21 mercapto derivatives as dissociated steroids: Discovery of an inhaled dissociated steroid
Biju, Purakkattle,McCormick, Kevin,Aslanian, Robert,Berlin, Michael,Solomon, Daniel,Chapman, Richard,McLeod, Robbie,Prelusky, Daniel,Eckel, Stephen,Kelly, George,Natiello, Michelle,House, Aileen,Fernandez, Xiomara,Bitar, Rema,Phillips, Jonathan,Anthes, John
scheme or table, p. 6343 - 6347 (2011/12/02)
A series of C-21 mercapto derivatives of hydrocortisone have been synthesized and evaluated in cell based transrepression and transactivation assays. The benzothiazole derivative, compound 6 not only showed a dissociated profile in vitro functional assays but also a pharmacological profile in a Brown-Norway rat therapeutic index model of asthma that dissociated side effects (thymolysis) while maintaining efficacy against pulmonary inflammation and lung function.