354117-24-1

Basic information

• Product Name: (2S,3aS,8aR)-2-methoxymethyl-2,3,3a,8a-tetrahydro-pyrrolo[2,3-b]indole-1,2,8-tricarboxylic acid 2-allyl ester 1,8-dibenzyl ester
• Synonyms: (2S,3aS,8aR)-2-methoxymethyl-2,3,3a,8a-tetrahydro-pyrrolo[2,3-b]indole-1,2,8-tricarboxylic acid 2-allyl ester 1,8-dibenzyl ester
• CAS NO: 354117-24-1
• Molecular Weight: 556.615
• Mol File: 354117-24-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,3aS,8aR)-2-methoxymethyl-2,3,3a,8a-tetrahydro-pyrrolo[2,3-b]indole-1,2,8-tricarboxylic acid 2-allyl ester 1,8-dibenzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3aS,8aR)-2-methoxymethyl-2,3,3a,8a-tetrahydro-pyrrolo[2,3-b]indole-1,2,8-tricarboxylic acid 2-allyl ester 1,8-dibenzyl ester(354117-24-1)
• EPA Substance Registry System: (2S,3aS,8aR)-2-methoxymethyl-2,3,3a,8a-tetrahydro-pyrrolo[2,3-b]indole-1,2,8-tricarboxylic acid 2-allyl ester 1,8-dibenzyl ester(354117-24-1)

Safety Data

• Hazardous Substances Data: 354117-24-1(Hazardous Substances Data)

Upstream product

• 2279-15-4 N-(benzyloxycarbonyl)-D-tryptophan 
• 13057-19-7 Iodomethyl methyl ether 
• 354117-19-4 (2R,3aS,8aS)-3,3a,8,8a-tetrahydro-2H-pyrrolo[2,3-b]indole-1,2-dicarboxylic acid 2-allyl ester 1-benzyl ester 
• 346440-85-5 (R)-2-benzyloxycarbonylamino-3-(1H-indol-3-yl)propionic acid allyl ester 
• 354117-18-3 (2R,3aS,8aS)-3,3a,8,8a-tetrahydro-2H-pyrrolo[2,3-b]indole-1,2-dicarboxylic acid 2-allyl ester 1-benzyl ester 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 346440-95-7 3-[(R)-2-benzyloxycarbonylamino-3-methoxy-2-((S)-1-phenyl-ethylcarbamoyl)-propyl]-indole-1-carboxylic acid benzyl ester 
• 346440-93-5 3-((S)-2-benzyloxycarbonylamino-2-carboxy-3-methoxy-propyl)-indole-1-carboxylic acid benzyl ester 
• 346440-97-9 (S)-2-amino-3-(1H-indol-3-yl)-2-methoxymethyl-N-((S)-1-phenylethyl)-propionamide 
• 346440-91-3 3-((S)-2-allyloxycarbonyl-2-benzyloxycarbonylamino-3-methoxy-propyl)-indole-1-carboxylic acid benzyl ester 

Relevant articles and documents

Utilization of an intramolecular hydrogen bond to increase the CNS penetration of an NK1 receptor antagonist

This paper describes the synthesis and physical and biological effects of introducing different substituents at the α-position of the tryptophan containing neurokinin-1 receptor antagonist [(R)-2-(1H-indol-3-yl)-1-methyl-1-((S)-1 -phenyl-ethylcarbamoyl)-e