354153-65-4

Basic information

• Product Name: (S)-b-AMino-4-broMo-benzeneethanol
• Synonyms: (S)-b-AMino-4-broMo-benzeneethanol;(2S)-2-AMINO-2-(4-BROMOPHENYL)ETHAN-1-OL;(2S)-2-AMINO-2-(4-BROMOPHENYL)ETHAN-1-OL-HCL;(S)-2-amino-2-(4-bromophenyl)ethan-1-ol;(2S)-2-Amino-2-(4-bromophenyl)ethanol
• CAS NO: 354153-65-4
• Molecular Formula: C₈H₁₀BrNO
• Molecular Weight: 216.0751
• Mol File: 354153-65-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: (S)-b-AMino-4-broMo-benzeneethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-b-AMino-4-broMo-benzeneethanol(354153-65-4)
• EPA Substance Registry System: (S)-b-AMino-4-broMo-benzeneethanol(354153-65-4)

Safety Data

• Hazardous Substances Data: 354153-65-4(Hazardous Substances Data)

Usage

General Description

(S)-b-AMino-4-broMo-benzeneethanol is a chemical compound with the molecular formula C8H10BrNO. It is an organic compound that contains a benzene ring with a bromine and an amino group attached to it. (S)-b-AMino-4-broMo-benzeneethanol is chiral, meaning it has a non-superimposable mirror image, and the (S)-enantiomer refers to the stereochemistry of the molecule. It is commonly used in the pharmaceutical industry as an intermediate in the synthesis of various drugs and pharmaceuticals. The presence of the bromine and amino groups makes it a versatile compound for various chemical reactions and functional group transformations in organic synthesis. (S)-b-AMino-4-broMo-benzeneethanol is of interest to researchers and chemists for its potential use in the development of new pharmaceuticals and biologically active compounds.

Upstream product

• 201403-02-3 (+/-)-2-amino-2-(4-bromophenyl)ethanol 
• 3343-45-1 4-bromo-2-hydroxyacetophenone 
• 32017-76-8 (+/-)-2-(4-bromophenyl)oxirane 
• 169272-18-8 (S)-2-azido-2-(4-bromophenyl) ethan-1-ol 
• 2039-82-9 1-bromo-4-ethenyl-benzene 
• 354153-60-9 (S)-N-[(S)-1-(4-Bromo-phenyl)-2-hydroxy-ethyl]-2-hydroxy-2-phenyl-acetamide 

Relevant articles and documents

Enantioselective Cascade Biocatalysis for Deracemization of Racemic β-Amino Alcohols to Enantiopure (S)-β-Amino Alcohols by Employing Cyclohexylamine Oxidase and ω-Transaminase

Optically active β-amino alcohols are very useful chiral intermediates frequently used in the preparation of pharmaceutically active substances. Here, a novel cyclohexylamine oxidase (ArCHAO) was identified from the genome sequence of Arthrobacter sp. TYUT010-15 with the R-stereoselective deamination activity of β-amino alcohol. ArCHAO was cloned and successfully expressed in E. coli BL21, purified and characterized. Substrate-specific analysis revealed that ArCHAO has high activity (4.15 to 6.34 U mg?1 protein) and excellent enantioselectivity toward the tested β-amino alcohols. By using purified ArCHAO, a wide range of racemic β-amino alcohols were resolved, (S)-β-amino alcohols were obtained in >99 % ee. Deracemization of racemic β-amino alcohols was conducted by ArCHAO-catalyzed enantioselective deamination and transaminase-catalyzed enantioselective amination to afford (S)-β-amino alcohols in excellent conversion (78–94 %) and enantiomeric excess (>99 %). Preparative-scale deracemization was carried out with 50 mM (6.859 g L?1) racemic 2-amino-2-phenylethanol, (S)-2-amino-2-phenylethanol was obtained in 75 % isolated yield and >99 % ee.

Synthesis of highly modular bis(oxazoline) ligands by Suzuki cross-coupling and evaluation as catalytic ligands

New bis(oxazoline) ligands (BOXs) containing biaryl substitutents at the C-4 position and H or CH2OR substituents at the C-5 position have been synthesized using Suzuki cross-coupling as the main tool for structural diversity. Copper, zinc, and