354153-65-4

Usage

Uses

Used in Pharmaceutical Industry:
(S)-b-AMino-4-broMo-benzeneethanol serves as a crucial intermediate in the synthesis of a variety of drugs and pharmaceuticals. Its unique structure, including the bromine and amino groups, facilitates its role in the creation of biologically active compounds, making it an essential component in medicinal chemistry.
Used in Organic Synthesis:
In the field of organic synthesis, (S)-b-AMino-4-broMo-benzeneethanol is utilized for its capacity to undergo various chemical reactions and functional group transformations. This adaptability positions it as a valuable building block for the development of new chemical entities with potential applications across different industries.
Used in Research and Development:
(S)-b-AMino-4-broMo-benzeneethanol is of significant interest to researchers and chemists due to its potential in the development of innovative pharmaceuticals and biologically active compounds. Its unique properties and reactivity make it a promising candidate for exploration in scientific studies aimed at advancing the frontiers of medicine and chemistry.

Upstream product

• 201403-02-3 (+/-)-2-amino-2-(4-bromophenyl)ethanol 
• 169272-18-8 (S)-2-azido-2-(4-bromophenyl) ethan-1-ol 
• 32017-76-8 (+/-)-2-(4-bromophenyl)oxirane 
• 3343-45-1 4-bromo-2-hydroxyacetophenone 
• 2039-82-9 1-bromo-4-ethenyl-benzene 
• 354153-60-9 (S)-N-[(S)-1-(4-Bromo-phenyl)-2-hydroxy-ethyl]-2-hydroxy-2-phenyl-acetamide 

Relevant academic research and scientific papers

Enantioselective Cascade Biocatalysis for Deracemization of Racemic β-Amino Alcohols to Enantiopure (S)-β-Amino Alcohols by Employing Cyclohexylamine Oxidase and ω-Transaminase

Optically active β-amino alcohols are very useful chiral intermediates frequently used in the preparation of pharmaceutically active substances. Here, a novel cyclohexylamine oxidase (ArCHAO) was identified from the genome sequence of Arthrobacter sp. TYUT010-15 with the R-stereoselective deamination activity of β-amino alcohol. ArCHAO was cloned and successfully expressed in E. coli BL21, purified and characterized. Substrate-specific analysis revealed that ArCHAO has high activity (4.15 to 6.34 U mg?1 protein) and excellent enantioselectivity toward the tested β-amino alcohols. By using purified ArCHAO, a wide range of racemic β-amino alcohols were resolved, (S)-β-amino alcohols were obtained in >99 % ee. Deracemization of racemic β-amino alcohols was conducted by ArCHAO-catalyzed enantioselective deamination and transaminase-catalyzed enantioselective amination to afford (S)-β-amino alcohols in excellent conversion (78–94 %) and enantiomeric excess (>99 %). Preparative-scale deracemization was carried out with 50 mM (6.859 g L?1) racemic 2-amino-2-phenylethanol, (S)-2-amino-2-phenylethanol was obtained in 75 % isolated yield and >99 % ee.

Asymmetric ring opening of racemic epoxides for enantioselective synthesis of (S)-β-amino alcohols by a cofactor self-sufficient cascade biocatalysis system

A novel one-pot epoxide hydrolase/alcohol dehydrogenase/transaminase cascade process for the asymmetric ring opening of racemic epoxides to enantiopure β-amino alcohols is reported. The product (S)-β-amino alcohols were obtained in 97-99% ee and 79-99% conversion from readily available racemic epoxides.

Synthesis of highly modular bis(oxazoline) ligands by Suzuki cross-coupling and evaluation as catalytic ligands

New bis(oxazoline) ligands (BOXs) containing biaryl substitutents at the C-4 position and H or CH2OR substituents at the C-5 position have been synthesized using Suzuki cross-coupling as the main tool for structural diversity. Copper, zinc, and

An effective and useful synthesis of enantiomerically enriched arylglycinols

A two-step synthesis of racemic arylglycinols, together with a simple and straightforward methodology for their resolution, is described. This method constitutes a practical means of preparing racemic and optically pure electron-rich or electron-poor subs