3542-00-5Relevant articles and documents
Mechanism of the formation of 1,2,4-thiadiazoles by condensation of aromatic thioamides and of N-substituted thioureas
Forlani, Luciano,Lugli, Andrea,Boga, Carla,Corradi, Anna Bonamartini,Sgarabotto, Paolo
, p. 63 - 69 (2007/10/03)
The condensation reaction of thiobenzamide, (as well as thionicotinamide and isothionicotinamide) in the presence of dimethyl sulfoxide and of an acid, affords 3,5-diphenyl-1,2,4-thiadiazole. Under the same experimental conditions, N-substituted thioureas are also condensed to 1,2,4-thiadiazole derivatives; their structure is ascertained by spectroscopic properties and by X-ray diffraction. Some information on the mechanism of thiadiazoles formation from both starting classes of compounds, thiobenzamides and N- substituted thiourea, is collected and discussed.
