3543-31-5

Upstream product

• 108-86-1 bromobenzene 
• 92703-36-1 1-benzyl-4-dimethylamino-piperidine-4-carbonitrile 
• 3612-20-2 1-phenylmethyl-4-piperidone 

Downstream Products

• 1181285-55-1 benzyloxycarbonyl-4-(dimethylamino)-4-phenylpiperidine 
• 46367-53-7 N,N-dimethyl-4-phenylpiperidin-4-amine 
• 1181285-75-5 C₂₁H₃₃N₃O₃ 
• 1181282-52-9 N-(2-(4-(dimethylamino)-4-phenylpiperidin-1-yl)ethyl)-5-fluoro-N-methyl-1H-indole-2-carboxamide 
• 1181282-54-1 N-(2-(4-(dimethylamino)-4-phenylpiperidin-1-yl)ethyl)-3-(1H-indol-3-yl)-N-methylpropanamide 
• 1181282-48-3 N-(2-(4-(dimethylamino)-4-phenylpiperidin-1-yl)ethyl)-N-methyl-1H-indole-6-carboxamide 
• 1181285-56-2 tert-Butyl 2-(4-(dimethylamino)-4-phenylpiperidin-1-yl)ethyl(methyl)-carbamate 
• 1181285-54-0 tert-butyloxycarbonyl-4-(dimethylamino)-4-phenylpiperidine 

Relevant academic research and scientific papers

Substituted Indole Compounds

Substituted indole compounds corresponding to the formula I: In which R8, R9a, R9b, R10, R11, R200, R210, A, D, T, q, s and t have defined meanings, processes for the preparation thereof, pharmaceutical compositions containing such compounds and the use of substituted indole compounds for the treatment or inhibition of pain and other conditions which are at least partly mediated by Bradykinin 1 receptors (B1R).

Substituted Pyrimidine and Triazine Compounds

Substituted pyrimidine and triazine compounds corresponding to formula I wherein R1, R2, R3, R4a, R4b, R5a, R5b, R7, R8, R9a, R9b, R10, R11, A, a, b, s, t, V, W1, W2 and W3 have defined meanings, pharmaceutical compositions comprising such compounds, a process for preparing such compounds, and the use of such compounds and compositions to treat or inhibit pain and/or other disorders or disease states.

Substituted indole derivatives

Substituted indole derivatives, processes for the preparation thereof, medicinal products and pharmaceutical compositions containing these compounds and the use of substituted indole derivatives to treat pain and other conditions and for other medical purposes.

SUBSTITUTED INDOLE DERIVATIVES

The present invention relates to substituted indole derivatives having the general formula (I) which act on the ORL 1 receptor wherein A and B mutually independently denote CH2, C=O or SO2, X stands for indolyl, unsubstituted or mono- or polysubstituted; T stands for (CR5a-cR6a-c)n, n = 1, 2 or 3, and Q stands for (CR7a-cR8a-c)m, m = 0,1, 2 or 3, processes for the preparation thereof, medicinal products containing these compounds and the use of substituted indole derivatives for the preparation of medicinal products.