3543-46-2

Usage

Uses

Used in Pharmaceutical Industry:
5-Bromo-4-phenylpyrimidine is used as a building block for the synthesis of various pharmaceutical drugs and intermediates. Its unique structure and reactivity make it a valuable component in the development of new medications, contributing to the creation of a wide array of different compounds.
Used in Research Laboratories:
In research settings, 5-Bromo-4-phenylpyrimidine serves as a key intermediate for the development of new chemical processes and materials. Its properties allow scientists to explore innovative approaches in chemical synthesis and material science, potentially leading to breakthroughs in various fields.

Upstream product

• 3438-56-0 5-bromo-4-chloro-6-phenylpyrimidine 
• 4595-59-9 5-bromopyrimidine 
• 98-80-6 phenylboronic acid 
• 3438-48-0 4-phenylpyrimidine 

Downstream Products

• 3438-48-0 4-phenylpyrimidine 
• 88070-43-3 5-Hydroxy-4-phenylpyrimidine 
• 114969-93-6 5-methoxy-4-phenylpyrimidine 
• 114969-73-2 5-Methoxy-6-phenyl-pyrimidine-4-carbonitrile 
• 114969-69-6 5-Methoxy-4-phenyl-pyrimidine-2-carbonitrile 
• 69098-68-6 5-methoxy-4-phenyl-pyrimidine 1-oxide 
• 88467-02-1 2,6-Bis(diethylaminomethyl)-4-phenyl-5-hydroxypyrimidine 1-Oxide 
• 88467-01-0 2,6-Bis(morpholinomethyl)-4-phenyl-5-hydroxypyrimidine 1-Oxide 
• 88467-03-2 2,6-Bis(dimethylaminomethyl)-4-phenyl-5-hydroxypyrimidine 1-Oxide 
• 88466-98-2 4-Morpholinomethyl-5-hydroxy-6-phenylpyrimidine 
• 88466-99-3 4-Piperidinomethyl-5-hydroxy-6-phenylpyrimidine 
• 88070-45-5 4-Phenyl-5-hydroxypyrimidine 1-Oxide 
• 88467-00-9 4-Iodo-5-hydroxy-6-phenylpyrimidine 

Relevant academic research and scientific papers

Metal free C-H functionalization of diazines and related heteroarenes with organoboron species and its application in the synthesis of a CDK inhibitor, meriolin 1

Here, we report a metal-free cross-coupling reaction of diazines and related heteroarenes with organoboron species via C-H functionalization. The optimized conditions represent a metal-free method for the activation of aryl/heteroarylboronic acids, which undergo coupling with diazines and related heteroarenes. Optimized conditions also find application in the synthesis of a pyrimidine-based potent CDK inhibitor, meriolin1.

Studies on Pyrimidine Derivatives. XXXIX. Site-Selectivity in the Reaction of 5-Substituted and 4,5-Disubstituted Pyrimidine N-Oxides with Trimethylsilyl Cynanide

The site-selectivity in the modified Reissert-Henze reaction of 5-substituted and 4,5-disubstituted pyrimidine 1-oxides with trimethylsilyl cyanide was examined.The reaction of 5-substituted 4-methoxypyrimidine 1-oxides with trimethylsilyl cyanide gave exclusively 2-pyrimidinecarbonitriles in good yields without exception.On the other hand, the other 5-substituted and 4,5-disubstituted pyrimidine 1-oxides gave mainly 6-pyrimidinecarbonitriles.Keywords--site-selectivity; pyrimidine N-oxide; trimethylsilyl cyanide; Reissert-Henze reasction; pyrimidinecarbonitrile

INVESTIGATION OF SOME ELECTROPHILIC REACTIONS OF 4-PHENYL-5-HYDROXYPYRIMIDINE AND ITS 1-OXIDE

A difference in the reactivities of the 2 and 6 positions of the 5-hydroxypyrimidine ring and an effect of the N-oxide group on the direction of electrophilic substitution reactions were demonstrated in the case of synthesized 4-phenyl-5-hydroxypyrimidine and its 1-oxide.