35455-86-8

Upstream product

• 22576-11-0 1-methyl-4-(methylsulfanyl)pyrimidine-2(1H)-thione 
• 49844-94-2 1-methyl-4-(methylsulfanyl)pyrimidin-2(1H)-one 
• 615-77-0 1-methyluracil 

Downstream Products

• 1122-47-0 1-MeCyt 
• 74203-17-1 4-[2-(4-Bromo-phenyl)-2-oxo-ethylsulfanyl]-1-methyl-1H-pyrimidin-2-one 
• 263551-24-2 C₁₃H₁₀N₂O₂S 
• 74195-35-0 1-Methyl-4(3H)-<(4-bromobenzoyl)methenyl>-2-pyrimidinone 

Relevant academic research and scientific papers

Straightforward pyrimidine ring construction: A versatile tool for the synthesis of nucleobase and nucleoside analogues

A general route to 1,2,4-trisubstituted pyrimidines is described in one to three steps from a common key precursor, diazadienium iodide 2. An efficient preliminary [4+2] cyclocondensation reaction between the azabutadiene building block 2 and various iso(thio)cyanates constitutes an original construction of the pyrimidine skeleton. Subsequent structural modifications on the heterocycle allow the elaboration of a 1-substituted pyrimidine library that includes nucleoside analogues. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.

An efficient synthesis of 1-substituted uracil ring systems and their thio analogues

A facile and simple regioselective synthesis of uracils and their thio analogues has been achieved by cyclocondensation of a common precursor, diazadienium iodide 1, and isothiocyanates 2a,b. The key step in this synthetic process is the preparation of 4-