354556-16-4Relevant academic research and scientific papers
Synthetic studies towards diazepanone scaffolds
Monasson, Olivier,Ginisty, Maryon,Mravljak, Janez,Bertho, Gildas,Gravier-Pelletier, Christine,Le Merrer, Yves
experimental part, p. 2320 - 2330 (2010/03/25)
The synthesis of new enantiopure polyfunctionalised diazepanone scaffolds is described. The key steps involve the opening of an azido-epoxide C4 building block derived from l-ascorbic or d-isoascorbic acid by a l-serine derivative followed by a lactonisation-lactamisation two-step sequence.
Efficient synthesis of polyfunctionalised enantiopure diazepanone scaffolds
Monasson, Olivier,Ginisty, Maryon,Bertho, Gildas,Gravier-Pelletier, Christine,Le Merrer, Yves
, p. 8149 - 8152 (2008/03/13)
The synthesis of polyfunctionalised enantiopure 1,4-diazepan-3-one scaffolds from l-serine derivatives and azidoepoxides readily available from either l-ascorbic or d-isoascorbic acid, allowing access to various configurations at chiral centres, is descri
Porcine pancreatic lipase mediated regio- and stereoselective hydrolysis: Chemoenzymatic synthesis of (2S,3S)-2-amino-3,4-dihydroxybutyric acid
Fadnavis,Sharfuddin,Vadivel
, p. 691 - 693 (2007/10/03)
Porcine pancreatic lipase was used in the chemoenzymatic hydrolysis of 2-azido-3-hydroxy-4-methylcarbonyloxybutyl acetate. The reaction occurred with high regio- and stereoselectivity to give enantiomerically pure (2S,3R)-3-azido-2,4-dihydroxy butyl aceta
