35457-38-6Relevant academic research and scientific papers
BIOSYNTHESIS OF HYGRINE FROM ORNITHINE VIA A SYMMETRICAL INTERMEDIATE IN NICANDRA PHYSALOIDES
Leete, Edward
, p. 953 - 956 (1985)
Radioactive hygrine (2.2 percent incorporation) was isolated from Nicandra physaloides plants which had been fed DL-ornithine.A systematic degradation of the hygrine yielded products whose activity was consistent with the pyrrolidine ring of this alkaloid being labeled equally at the C-2 and C-5 positions.The result does not agree with the previous work of O'Donovan and Keogh, whose publication is critically examined.Key Word Index - Nicandra physaloides; Solanaceae; biosynthesis; ornithine; hygrine.
THE BIOSYNTHESIS OF GLAUCINE IN LITSEA GLUTINOSA
Bhakuni, Dewan S.,Jain, Sudha
, p. 1447 - 1450 (2007/10/02)
Incorporation of 14C labelled (+/-)-reticuline and tritiated racemic reticuline, protosinomenine, orientaline, laudanosine, isoboldine, boldine, thaliporphine, N-methyl-laurotetanine, and dicentrine into glaucine in young Litsea glutinosa (Lour) C.B.Rob. var. glabraria Hook f. (Lauraceae) has been studied.The results provide evidence that (S)-reticuline (5) is converted by oxidative couplung into (S)-isoboldine (6) and methylation via (S)-thaliporphine (7) to form (S)-glaucine (8).
Studies in Terpenoid Biosynthesis. Part 35. Biosynthetic Sequences leading to the Diterpenoid Aphidicolin in Cephalosporium aphidicola
Ackland, Mark J.,Gordon, John F.,Hanson, James R.,Yeoh, Boon Leng,Ratcliffe, Arnold H.
, p. 1477 - 1480 (2007/10/02)
-Labelled samples of 18-hydroxyaphidicol-16-ene, 3α,18-dihydroxyaphidicol-16-ene, 16β,17- and 16β,18-dihydroxyaphidicolane, and 3α,16β,18- and 16β,17,18-triyhdroxyaphidicolane have been prepared from aphidicolin and shown to be incorporated into aphidicolin by Cephalosporium aphidicola to the extent of 0.86, 16.4, 3.5, 20.5, 52.6, and 16,9 percent , respectively.These results suggest that although the major pathway of aphidicolin biosynthesis involves the 16β-alcohols , the 16-enes may also utilized whilst a metabolic grid relationship may exist between the variously hydroxylated 16β-alcohols.
THE BIOSYNTHESIS OF THE ALKALOIDS OF STEPHANIA GLABRA (ROXB.) MIERS
Bhakuni, Dewan S.,Gupta, Sandeep,Jain, Sudha
, p. 4003 - 4010 (2007/10/02)
Tracer experiments show that the tetrhydroprotoberberines stepholidine (14), corydalmine (15), capaurine (19) and corynoxidine (20) are stereospecifically biosynthesized from (S)-reticuline (22) whereas the bisbenzylisoquinoline alkaloids cycleanine (52),
