354584-66-0

Upstream product

• 65902-08-1 (S)-N-(1,2,3,4-tetrahydro-naphthalen-1-yl)acetamide 
• 23357-52-0 (S)-1,2,3,4-tetrahydronapht-1-yl-amine 

Relevant academic research and scientific papers

3-SUBSTITUTED-6-ARYL PYRIDINES

3-substituted-6-aryl pyridines of Formula (I) are provided: Formula (I) wherein R1, R2, R3, R8, R9, A and Ar are defined herein. Such compounds are ligands of C5a receptors. Preferred compounds of Formula (I) bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. The present invention also relates to pharmaceutical compositions comprising such compounds, and to the use of such compounds in treating a variety of inflammatory, cardiovascular, and immune system disorders. In addition, the present invention provides labeled 3-substituted-6-aryl pyridines, which are useful as probes for the localization of C5a receptors.

Rational design of novel axially chiral NADH models based on configurational control of atropisomeric lactams

The preparation of a new class of axially chiral NADH models based on configurational control of atropisomeric lactams is described. The configurational control of this chiral axis is achieved via the presence of a second chirality element installed on th