354584-98-8

Upstream product

• 354584-97-7 (-)-methyl (1R,2R,4R,6S)-4,6-dimethyl-5-oxobicyclo[2.2.2]octane-2-carboxylate 
• 354584-94-4 (-)-methyl (1R,2R,4S,6S,8R)-8-hydroxy-4,6-dimethyl-5-oxobicyclo[2.2.2]octane-2-carboxylate 
• 6485-40-1 (R)-Carvone 
• 354584-93-3 (-)-methyl (1R,2R,4S,6S,8R)-8-acetoxy-4,6-dimethyl-5-oxobicyclo[2.2.2]octane-2-carboxylate 
• 130542-95-9 (-)-methyl (1R,2R,4S,6S,8S)-8-isopropenyl-4,6-dimethyl-5-oxobicyclo[2.2.2]octane-2-carboxylate 
• 354584-96-6 C₁₄H₂₀O₃S₂ 
• 354584-95-5 (-)-methyl (1R,2R,4S,6S)-4,6-dimethyl-5,8-dioxobicyclo[2.2.2]octane-2-carboxylate 
• 138812-34-7 (R)-6-methylcarvone 

Relevant academic research and scientific papers

An enantiospecific synthesis of (-)-2-pupukeanone via a rhodium carbenoid C-H insertion reaction

An enantiospecific synthesis of (-)-2-pupukeanone, starting from (R)-carvone employing a Michael-Michael reaction and an intramolecular rhodium carbenoid C-H insertion reaction as the key steps for the generation of the isotwistane framework, is described

An enantiospecific synthesis of 2-pupukeanone

A combination of intermolecular Michael addition followed by intramolecular Michael addition of an enone to methyl acrylate and an intramolecular rhodium carbenoid CH insertion reaction of a diazo ketone have been exploited for the construction of isotwistanes. It has been extended to racemic and enantiospecific synthesis of 2-pupukeanone.