35467-98-2

Basic information

• Product Name: 2-HYDROXY-5-METHOXY-BETA-NITROSTYRENE
• Synonyms: 2-HYDROXY-5-METHOXY-BETA-NITROSTYRENE;2-HYDROXY-5-METHOXY-BETA-NITROSTYRENE, >95%;(E)-4-methoxy-2-(2-nitrovinyl)phenol
• CAS NO: 35467-98-2
• Molecular Formula: C₉H₉NO₄
• Molecular Weight: 195.1721
• Mol File: 35467-98-2.mol
• Article Data: 12

Chemical Properties

• Melting Point: 153-153.5 °C(Solv: benzene (71-43-2))
• Boiling Point: 376.9°Cat760mmHg
• Flash Point: 181.7°C
• Appearance: /
• Density: 1.308g/cm³
• Vapor Pressure: 3.24E-06mmHg at 25°C
• Refractive Index: 1.615
• PKA: 8.44±0.43(Predicted)
• CAS DataBase Reference: 2-HYDROXY-5-METHOXY-BETA-NITROSTYRENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-5-METHOXY-BETA-NITROSTYRENE(35467-98-2)
• EPA Substance Registry System: 2-HYDROXY-5-METHOXY-BETA-NITROSTYRENE(35467-98-2)

Safety Data

• Hazardous Substances Data: 35467-98-2(Hazardous Substances Data)

Usage

General Description

2-HYDROXY-5-METHOXY-BETA-NITROSTYRENE is a chemical compound with the molecular formula C9H9NO4. It is a beta-nitrostyrene derivative, which is a type of organic compound containing a nitro group attached to a benzene ring. This chemical is a yellow crystalline solid, and it is known for its use in organic synthesis and medicinal chemistry. It has been studied for its potential pharmacological properties, including anti-inflammatory and anticancer effects. The 2-HYDROXY-5-METHOXY-BETA-NITROSTYRENE compound is of interest to researchers for its potential applications in the development of new drugs and biologically active molecules.

InChI:InChI=1/C9H9NO4/c1-14-8-2-3-9(11)7(6-8)4-5-10(12)13/h2-6,11H,1H3/b5-4+

Upstream product

• 672-13-9 2-hydroxy-5-methoxybenzaldehyde 
• 75-52-5 nitromethane 

Downstream Products

• 30335-72-9 methoxy-5 nitro-2 benzofuranne 
• 96853-38-2 4-Methoxy-2-(2-nitro-ethyl)-phenol 
• 40024-32-6 5-hydroxy-2-nitrobenzofuran 
• 1043869-18-6 5-iodo-4-methoxy-2-(2-((2-methoxybenzyl)amino)ethyl)phenol 

Relevant articles and documents

Regio- and Stereoselective Cascade of β,γ-Unsaturated Ketones by Dipeptided Phosphonium Salt Catalysis: Stereospecific Construction of Dihydrofuro-Fused [2,3-b] Skeletons

Chiral (dihydro)furo-fused heterocycles are significant structural motifs in numerous natural products, functional materials and pharmaceuticals. Therefore, developing efficient methods for preparing compounds with these privileged scaffolds is an important endeavor in synthetic chemistry. Herein, we develop an effective, modular method by a dipeptide-phosphonium salt-catalyzed regio- and stereoselective cascade reaction of readily available linear β,γ-unsaturated ketones with aromatic alkenes, affording a wide variety of structurally fused heterocyclic molecules in high yields with excellent stereoselectivities. Moreover, mechanistic investigations revealed that the bifunctional phosphonium salt controlled the regio- and stereoselectivities of this cascade reaction, particularly proceeding through the initial ketone α-addition followed by O-participated substitution; and the multiple hydrogen-bonding interactions between Br?nsted acid moieties of catalyst and nitro group of aromatic alkene were crucial in asymmetric induction. Given the generality, versatility, and high efficiency of this method, we anticipate that it will have broad synthetic utilities.

Phosphine-Catalyzed Enantioselective Dearomative [3+2]-Cycloaddition of 3-Nitroindoles and 2-Nitrobenzofurans

Over the past years, the metal-catalyzed dearomative cycloaddition of 3-nitroindoles and 2-nitrobenzofurans have emerged as a powerful protocol to construct chiral fused heterocyclic rings. However, organocatalytic dearomative reaction of these two classe

Enantioselective dearomative [3+2] cycloaddition of 2-nitrobenzofurans with aldehyde-derived Morita-Baylis-Hillman carbonates

The phosphine-catalyzed asymmetric dearomative [3+2] cycloaddition of 2-nitrobenzofurans with aldehyde-derived Morita-Baylis-Hillman (MBH) carbonates or allenoate was developed. The reaction with MBH carbonates resulted in a series of cyclopentabenzofurans containing three contiguous stereocenters with good to high yields, diastereoselectivities and enantioselectivities. The use of allenoate also gave the target product with moderate enantioselectivity.