35468-02-1

Basic information

• Product Name: (1E)-1-[1-(2-chlorophenyl)ethylidene]-2-(2,4-dinitrophenyl)hydrazine
• Synonyms: Ethanone, 1-(2-chlorophenyl)-, 2,4-dinitrophenylhydrazone
• CAS NO: 35468-02-1
• Molecular Formula: C₁₄H₁₁ClN₄O₄
• Molecular Weight: 334.7145
• Mol File: 35468-02-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 483.3°C at 760 mmHg
• Flash Point: 246.1°C
• Density: 1.45g/cm³
• Vapor Pressure: 1.7E-09mmHg at 25°C
• Refractive Index: 1.65
• CAS DataBase Reference: (1E)-1-[1-(2-chlorophenyl)ethylidene]-2-(2,4-dinitrophenyl)hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: (1E)-1-[1-(2-chlorophenyl)ethylidene]-2-(2,4-dinitrophenyl)hydrazine(35468-02-1)
• EPA Substance Registry System: (1E)-1-[1-(2-chlorophenyl)ethylidene]-2-(2,4-dinitrophenyl)hydrazine(35468-02-1)

Safety Data

• Hazardous Substances Data: 35468-02-1(Hazardous Substances Data)

Usage

General Description

The chemical (1E)-1-[1-(2-chlorophenyl)ethylidene]-2-(2,4-dinitrophenyl)hydrazine, also known as CDH, is a hydrazine derivative with a molecular formula of C14H11ClN6O4. It is a yellow to orange solid compound that is insoluble in water but soluble in organic solvents. CDH is widely used in the synthesis of various pharmaceuticals, agrochemicals, and dyes. It is also used as a reagent in organic chemistry for the detection and quantification of aldehydes and ketones. Additionally, CDH has potential applications in the treatment of neurological disorders and cancer due to its ability to inhibit certain enzymes and receptors in the body. However, it is important to handle this compound with caution as it is flammable and may cause irritation to the skin, eyes, and respiratory system.

Upstream product

• 2142-68-9 1-(2-chlorophenyl)ethanone 
• 76195-86-3 2,4-dinitrophenylhydrazine hydrochloride 
• 873-32-5 2-Chlorobenzonitrile 
• 119-26-6 (2,4-dinitro-phenyl)-hydrazine 

Downstream Products

• 2142-68-9 1-(2-chlorophenyl)ethanone 

Relevant articles and documents

Antibacterial evaluation and molecular docking studies of pyrazole–thiosemicarbazones and their pyrazole–thiazolidinone conjugates

A library of pyrazole–thiazolidinone conjugates was synthesized using a molecular hybridization approach through a Vilsmeier–Haack reaction. The compounds were tested for anti-microbial activity against two Gram-positive bacteria (Staphylococcus aureus and methicillin-resistant Staphylococcus aureus) and four Gram-negative bacteria (Escherichia coli, Salmonella typhimurium, Klebsiella pneumonia and Pseudomonas aeruginosa). Among the compounds tested, 3-((2,4-dichlorophenyl)-1-(2,4-dinitrophenyl)-1H-pyrazol-yl)methylene)hydrazinecarbothioamide (3a) and 2-((3-(2-chlorophenyl)-1-(2,4 dinitrophenyl)-1H-pyrazol-4-yl)methyleneamino)thiazolidin-4-one (4b) emerged as the most potent anti-microbial compounds with minimum bactericidal concentrations of 0.2?μM against MRSA and S. aureus. Structure–activity relationship analysis further revealed that the presence of 2,4-dichloro moiety surprisingly influenced the activity of the compounds. Molecular docking studies of the compounds into the crystal structure of topoisomerase II and topoisomerase IV suggest that compounds 3a and 4b preferably interact with the targets through hydrogen bonding.

Synthesis and antimicrobial evaluation of (Z)-5-((3-phenyl-1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one derivatives

Background: An alarming increment in pathogenic resistance to existing anti-microbial agents is a serious problem and the treatment of these bacterial infections is becoming increasingly challenging. Therefore, there is an urgent need to develop novel ant