35470-59-8Relevant academic research and scientific papers
Cytotoxic bisnor- and norditerpene dilactones having 7α,8α- epoxy-9,11-enolide substructure from Podocarpus macrophyllus D. Don
Sato, Kimihiko,Inaba, Yasunori,Park, Hyun-Sun,Akiyama, Toshiyuki,Koyama, Tetsuo,Fukaya, Haruhiko,Aoyagi, Yutaka,Takeya, Koichi
experimental part, p. 668 - 679 (2010/02/28)
Fourteen new bisnor- and norditerpene dilactones, makilactones E-R, having a 7α:8α-epoxy-9,11-enolide substructure, were isolated from a methanolic extract of the root and the bark of Podocarpus macrophyllus D. DON (Podocarpaceae) with thirteen known bisnor- and norditerpenoids, and the structures of those new bisnorand norditerpenoids were determined on the basis of their spectroscopic studies. Of the thirteen known ones isolated, the structures of two, i.e., podolactone B and inumakilactone B, were revised on the basis of X-ray crystallographic analysis and spectroscopic analysis. Many of the compounds of this type isolated in this study showed potent cytotoxic activities against P388 murine leukemia cells.
