354764-68-4

Basic information

• Product Name: N-(3-aminophenyl)-3-methoxybenzamide
• Synonyms: N-(3-aminophenyl)-3-methoxybenzamide
• CAS NO: 354764-68-4
• Molecular Formula: C₁₄H₁₄N₂O₂
• Molecular Weight: 242.27316
• Mol File: 354764-68-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(3-aminophenyl)-3-methoxybenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-aminophenyl)-3-methoxybenzamide(354764-68-4)
• EPA Substance Registry System: N-(3-aminophenyl)-3-methoxybenzamide(354764-68-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 354764-68-4(Hazardous Substances Data)

Upstream product

• 96875-09-1 3-methoxy-N-(3-nitrophenyl)benzamide 
• 1711-05-3 m-anisoyl chloride 
• 99-09-2 3-nitro-aniline 
• 586-38-9 3-Methoxybenzoic acid 

Downstream Products

• 1192927-81-3 3,4,5-trimethoxy-N-(((3-(3-methoxybenzoyl)aminophenyl)amino)carbonothioyl)benzamide 
• 420106-13-4 C₂₁H₁₈N₂O₃ 
• 1395923-28-0 C₂₅H₂₄N₂O₃ 
• 1395923-02-0 C₂₉H₂₄N₂O₃ 

Relevant articles and documents

Aza-acridine compound and preparation method and application thereof

The invention discloses a method for efficiently preparing an aza-acridine compound. The structural formula of the aza-acridine compound is shown as a formula I; the preparation method comprises the following steps: adding a 2-aminoquinoline-3-methanamide compound and a solvent under an air condition, and heating to reaction temperature; after the reaction is ended, separating and purifying to obtain multisubstituted acridine derivatives shown as the following formula, wherein the reaction temperature is 100 to 200DEG C, and the reaction time is 1 to 24 hours. A synthetic method of the aza-acridine compound, disclosed by the invention, has the advantages of scientificity, reasonability, simple and easily-operated synthesis process and high synthetic yield; a product is easy to purify. The invention also relates to the aza-acridine compound which can be used for inhibiting EGFR (Epidermal Growth Factor Receptor) and SrC, a preparation method of the aza-acridine compound, activity of a drug containing the aza-acridine compound and the application of the drug. The compound is shown in a formula II and can be used for preparing an EGFR and SrC activity inhibitor and a disease treatment medicine activated and mediated by the EGFR and the SrC.

Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold

TASK-1 is a two-pore domain potassium channel that is important to modulating cell excitability, most notably in the context of neuronal pathways. In order to leverage TASK-1 for therapeutic benefit, its physiological role needs better characterization; however, designing selective inhibitors that avoid the closely related TASK-3 channel has been challenging. In this study, a series of bis-amide derived compounds were found to demonstrate improved TASK-1 selectivity over TASK-3 compared to reported inhibitors. Optimization of a marginally selective hit led to analog 35 which displays a TASK-1 IC 50 = 16 nM with 62-fold selectivity over TASK-3 in an orthogonal electrophysiology assay.

N-Acylthiourea and N-Acylurea Inhibitors of the Hedgehog Protein Signalling Pathway

The present invention relates to the use of acylthiourea or acylurea derivatives for the treatment of pathologies involving a tissue dysfunction associated with a deregulation of the Hedgehog protein signalling pathway, and also to novel acylthiourea or a