354798-36-0Relevant academic research and scientific papers
Preparation of diphenylphosphinoserine and synthesis of other phosphine containing amino acids using zinc/copper reagents
Greenfield,Gilbertson
, p. 2337 - 2340 (2001)
Primary and secondary iodo amino acids are converted to zinc iodides. The resulting organozinc iodides are reacted with copper, and then coupled with aryl and alkyl phosphine chlorides in good to moderate yields.
Enantioselective [3 + 2]-cycloadditions catalyzed by a protected, multifunctional phosphine-containing α-amino acid
Cowen, Bryan J.,Miller, Scott J.
, p. 10988 - 10989 (2008/03/14)
Catalytic asymmetric [3 + 2]-cycloaddition reactions between α-allenic esters and enones are presented. We have found that a simple phosphine-containing protected α-amino acid derivative is capable of promoting such cycloadditions in high yields with significant levels of regioselectivity and enantioselectivity. Furthermore, employing chiral racemic γ-substituted allenoates in the cycloaddition with chalcone substrates results in a "deracemization" reaction furnishing cyclopentenes in high yields with up to 93% ee. Copyright
High asymmetric induction with β-turn-derived palladium phosphine complexes
Greenfield, Scott J.,Agarkov, Anton,Gilbertson, Scoff R.
, p. 3069 - 3072 (2007/10/03)
(Matrix presented) Work toward the development of a bisphosphine ligand system for the palladium-catalyzed addition to cyclic allyl acetates is reported. A parallel approach using phosphine-containing amino acids in conjunction with natural amino acids wa
