3548-91-2

Usage

InChI:InChI=1/2C9H11N.H2O4S/c2*10-9-6-8(9)7-4-2-1-3-5-7;1-5(2,3)4/h2*1-5,8-9H,6,10H2;(H2,1,2,3,4)

Upstream product

• 939-90-2 trans-2-phenylcyclopropane-1-carboxylic acid 
• 140-10-3 (E)-3-phenylacrylic acid 
• 939-87-7 (1SR,2SR)-2-phenylcyclopropanecarbonyl chloride 

Downstream Products

• 90874-45-6 N-methyl-trans-2-phenylcyclopropylamine hydrochloride 

Relevant academic research and scientific papers

The synergistic effect of copper chromite spinel nanoparticles (CuCr2O4) and basic ionic liquid on the synthesis of cyclopropanecarboxylic acids

Abstract: An efficient synthesis of cyclopropanecarboxylic acids using copper chromite spinel nanoparticles and basic ionic liquid is described. In this study, a relatively simple method starting with trans-cinnamic acid for the synthesis of (±)-trans-2-phenylcyclopropanecarboxylic acid, a key intermediate in the synthesis of tranylcypromine sulfate as an active pharmaceutical ingredient, was employed. Using a combination of basic ionic liquid [Bmim]OH and copper chromite spinel nanoparticles as a catalytic system, the best results were obtained in THF as a polar solvent. This method is a useful alternative to other approaches described in the literature. The use of commercially available chemicals, decreased environmental hazards, with no need for the separation of stereoisomers, and consequently a reduced number of overall steps, are the advantages of this approach that make it an appropriate choice at an increased scale. Graphical Abstract: [Figure not available: see fulltext.]

Method of synthesis of trans-2-phenylcyclopropylamine

An improved method of synthesis of trans-2-phenylcyclopropylamine wherein the improvement comprises isomerizing an intermediate ester, namely, cis,trans-ethyl-2-phenylcyclopropanecarboxylate, by reacting said ester with anhydrous sodium ethoxide, to form