35487-98-0

Basic information

• Product Name: 4(1H)-Pyridinone, 2,3-dihydro-1-(phenylmethyl)-
• CAS NO: 35487-98-0
• Molecular Formula: C12H13NO
• Molecular Weight: 187.241
• Mol File: 35487-98-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4(1H)-Pyridinone, 2,3-dihydro-1-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(1H)-Pyridinone, 2,3-dihydro-1-(phenylmethyl)-(35487-98-0)
• EPA Substance Registry System: 4(1H)-Pyridinone, 2,3-dihydro-1-(phenylmethyl)-(35487-98-0)

Safety Data

• Hazardous Substances Data: 35487-98-0(Hazardous Substances Data)

Upstream product

• 3612-20-2 1-phenylmethyl-4-piperidone 
• 1240530-49-7 tert-butyl benzyl(3-oxopent-4-ynyl)carbamate 
• 100-44-7 benzyl chloride 
• 27248-04-0 4-((trimethylsilyl)oxy)pyridine 
• 72359-37-6 1-benzylpyridin-4(1H)-one 

Downstream Products

• 1017601-66-9 1-benzyl-5-(3-hydroxyphenyl)-2,3-dihydropyridin-4(1H)-one 
• 1017601-65-8 1-benzyl-5-(3,4,5-trimethylphenyl)-2,3-dihydropyridin-4(1H)-one 
• 1017601-67-0 C₂₆H₂₄N₂O₃ 
• 1017601-54-5 C₁₆H₁₇NO₃ 
• 1017601-56-7 1-benzyl-5-phenyl-2,3-dihydropyridin-4(1H)-one 
• 1001078-59-6 1-benzyl-5-(4-methoxyphenyl)-2,3-dihydropyridin-4(1H)-one 
• 1017601-64-7 1-benzyl-5-(naphthalen-2-yl)-2,3-dihydropyridin-4(1H)-one 
• 1017601-57-8 1-benzyl-5-(4-tolyl)-2,3-dihydropyridin-4(1H)-one 
• 1017601-59-0 1-benzyl-5-(2-methoxyphenyl)-2,3-dihydropyridin-4(1H)-one 
• 1017601-58-9 1-benzyl-5-(2-tolyl)-2,3-dihydropyridin-4(1H)-one 
• 1017601-62-5 1-benzyl-5-(4-bromophenyl)-2,3-dihydropyridin-4(1H)-one 
• 1017601-61-4 1-benzyl-5-(4-acetylphenyl)-2,3-dihydropyridin-4(1H)-one 
• 1017601-63-6 1-benzyl-5-(4-chlorophenyl)-2,3-dihydropyridin-4(1H)-one 
• 1017601-60-3 1-benzyl-5-(4-(trifluoromethyl)phenyl)-2,3-dihydropyridin-4(1H)-one 

Relevant articles and documents

CeO2-Supported Pd(II)-on-Au Nanoparticle Catalyst for Aerobic Selective α,β-Desaturation of Carbonyl Compounds Applicable to Cyclohexanones

Direct selective desaturation of carbonyl compounds to synthesize α,β-unsaturated carbonyl compounds represents an environmentally benign alternative to classical stepwise procedures. In this study, we designed an ideal CeO2-supported Pd(II)-on-Au nanoparticle catalyst (Pd/Au/CeO2) and successfully achieved heterogeneously catalyzed selective desaturation of cyclohexanones to cyclohexenones using O2 in air as the oxidant. Besides cyclohexenones, various bioactive enones can also be synthesized from the corresponding saturated ketones under open air conditions in the presence of Pd/Au/CeO2. Preliminary mechanistic studies revealed that α-C-H bond cleavage in the substrates is the turnover-limiting step of this desaturation reaction.

Synthesis of 6- and 7-membered cyclic enaminones: Scope and mechanism

Six- and seven-membered cyclic enaminones can be prepared using common, environmentally benign reagents. Amino acids are used as synthetic precursors allowing diversification and the incorporation of chirality. The key reaction in this multistep process involves deprotection of Boc-amino ynones and subsequent treatment with methanolic K2CO3 to induce cyclization. A β-amino elimination side reaction was identified in a few labile substrates that led to either loss of stereochemical purity or degradation. This process can be mitigated in specific cases using mild deprotection conditions. NMR and deuterium-labeling experiments provided valuable insight into the workings and limitations of this reaction. Although disguised as a 6-endo-dig cyclization, the reagents employed in the transformation play a direct role in bond-making and bond-breaking, thus changing the mode of addition to a 6-endo-trig cyclization. This method can be used to construct an array of monocyclic and bicyclic scaffolds, many of which are found in well-known natural products (e.g., indolizidine, quinolizidine, and Stemona alkaloids).

Reduktion von 4-Pyridinonen

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