35489-88-4 Usage
Uses
Used in Biological Studies:
5-Hydroxy-3-phenylbenzoic acid is used as a lactate receptor agonist and antilipolytic agent in biological studies. It helps in the preparation and identification of hydroxybenzoic acids, which play a crucial role in modulating cellular metabolism and energy homeostasis.
Used in Drug Discovery:
5-Hydroxy-3-phenylbenzoic acid is used in the discovery of new series of BRD4(1) inhibitors. It is employed in protein-ligand docking and structure-guided design to develop novel therapeutic agents targeting bromodomain-containing protein 4 (BRD4), a protein involved in various cellular processes, including transcriptional regulation and cell cycle progression. These inhibitors have potential applications in the treatment of various diseases, including cancer and inflammatory disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 35489-88-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,5,4,8 and 9 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 35489-88:
(7*3)+(6*5)+(5*4)+(4*8)+(3*9)+(2*8)+(1*8)=154
154 % 10 = 4
So 35489-88-4 is a valid CAS Registry Number.
35489-88-4Relevant academic research and scientific papers
Iodine-Catalyzed Oxidative Aromatization: A Metal-Free Concise Approach to meta-Substituted Phenols from Cyclohex-2-enones
Wang, Shi-Ke,Chen, Ming-Tao,Zhao, Da-Yuan,You, Xia,Luo, Qun-Li
, p. 4093 - 4099 (2016/12/30)
A metal-free approach to meta-substituted phenols from cyclohex-2-enone via catalytic oxidative aromatization has been developed. The transformations are initiated with a catalytic amount of molecular iodine as the direct oxidant, while dimethyl sulfoxide is employed as the terminal oxidant. This practical approach is capable of avoiding the use of metal promoters and costly reagents, the lengthy synthesis, and overoxidation of products, and thus facilitates the efficient construction of meta-substituted phenol derivatives from inexpensive commercial chemicals under mild conditions. The synthetic utility of this approach is evident in the de novo syntheses of two bioactive molecules with good total yields, in which easily available chemicals were employed, protective groups were not utilized, and no unwanted carbon atoms were removed in each step. (Figure presented.).
