355-28-2

Basic information

• Product Name: 1H,1H-PERFLUOROPENTAN-1-OL
• Synonyms: 1H,1H-NONAFLUOROHEPTAN-1-OL;1H,1H-NONAFLUOROPENTAN-1-OL;1H,1H-NONAFLUOROPENTANOL-1;1H,1H-PERFLUOROPENTAN-1-OL;4:1 FTOH;1H,1H-Nonafluoropentan-1-ol 97%;1H,1H-Nonafluoropentan-1-ol97%;(Perfluorobutyl)methanol
• CAS NO: 355-28-2
• Molecular Formula: C₅H₃F₉O
• Molecular Weight: 250.06
• Mol File: 355-28-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 110-111°C
• Flash Point: 9.9 °C
• Appearance: /
• Density: 1,664 g/cm3
• Vapor Pressure: 30.6mmHg at 25°C
• Refractive Index: 1.3
• PKA: 12.58±0.10(Predicted)
• CAS DataBase Reference: 1H,1H-PERFLUOROPENTAN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 1H,1H-PERFLUOROPENTAN-1-OL(355-28-2)
• EPA Substance Registry System: 1H,1H-PERFLUOROPENTAN-1-OL(355-28-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 355-28-2(Hazardous Substances Data)

Usage

Description

1H,1H-Perfluoropentan-1-ol, a synthetic chemical compound, is a member of the (per)fluoroalkyl alcohols class. It features a five-carbon chain that is fully fluorinated, with all hydrogen atoms replaced by fluorine atoms, and an alcohol group (-OH) at one end. This structure endows the compound with high stability, non-reactivity, and resistance to heat, chemical reactions, and biological degradation. However, these properties also contribute to its environmental persistence and bioaccumulation in organisms, leading to health and ecological concerns.

Uses

Used in Industrial Applications:
1H,1H-Perfluoropentan-1-ol is used as a component in various industrial applications due to its stability, non-reactivity, and resistance to heat and chemical reactions. Its properties make it suitable for use in demanding environments and processes where other compounds may degrade or react undesirably.
Used in Environmental Remediation:
1H,1H-Perfluoropentan-1-ol can be employed as a component in environmental remediation technologies, leveraging its stability and resistance to degradation to address contamination issues in various settings.
Used in Research and Development:
The unique properties of 1H,1H-Perfluoropentan-1-ol make it a valuable compound for research and development in the fields of chemistry, materials science, and environmental science. It can be used to study the effects of fluorination on compound behavior and to develop new applications and technologies based on its characteristics.
Used in Specialty Chemicals:
1H,1H-Perfluoropentan-1-ol is used as a specialty chemical in various industries, such as pharmaceuticals, where its unique properties can be harnessed to create new compounds or improve existing ones.

InChI:InChI=1/C5H3F9O/c6-2(7,1-15)3(8,9)4(10,11)5(12,13)14/h15H,1H2

Upstream product

• 2706-90-3 Perfluoropentanoic acid 
• 424-36-2 2,2,3,3,4,4,5,5,5-nonafluoropentanoic acid ethyl ester 
• 13038-26-1 methyl perfluoropentanoate 

Downstream Products

• 375-53-1 perfluoropentanal 
• 883499-79-4 2,2,3,3,4,4,5,5,5-nonafluoropentyl 4-methylbenzenesulfonate 
• 1415681-36-5 N-(2,2,3,3,4,4,5,5,5-nonafluoropentyl 11-undecanoate)-N’,N”-di(n-decyl)benzene-1,3,5-tricarboxamide 
• 1384267-34-8 C₁₇H₁₉F₉N₂O 
• 125888-92-8 Phosphorochloridic acid 2,2,3,3,4,4,5,5,5-nonafluoro-pentyl ester 2,2,2-trifluoro-1-(3-trifluoromethyl-phenyl)-ethyl ester 
• 125888-91-7 Phosphorochloridic acid 2,2,3,3,4,4,5,5,5-nonafluoro-pentyl ester 2,2,2-trifluoro-1-phenyl-ethyl ester 
• 183997-44-6 1-Nitro-4-(2,2,3,3,4,4,5,5,5-nonafluoro-pentyloxy)-benzene 
• 70508-49-5 Phosphorochloridic acid 2,2,3,3,4,4,5,5,5-nonafluoro-pentyl ester phenyl ester 
• 70508-50-8 Phosphoric acid bis-(2,2,3,3,4,4,5,5,5-nonafluoro-pentyl) ester phenyl ester 
• 100664-11-7 Phosphoric acid bis-(2,2,3,3,4,4,5,5,5-nonafluoro-pentyl) ester 2,2,2-trifluoro-1-m-tolyl-ethyl ester 
• 308-26-9 acrylic acid-(1H,1H-nonafluoro-pentyl ester) 

Relevant articles and documents

Incorporation of a 3-(2,2,2-Trifluoroethyl)-γ-hydroxy-γ-lactam motif in the side chain of 4-aminoquinolines. Syntheses and antimalarial activities

In this paper we report the synthesis and antimalarial properties of two series of fluoroalkylated γ-lactams derived from 4-aminoquinoline as potent chemotherapeutic agents for malaria treatment. These molecules obtained in several steps resulted in the identification of very potent structures with in vitro activity against Plasmodium falciparum clones of variable sensitivity (3D7 and W2) in the range of 19-50 nM with resistance indices in the range of 1.0-2.5. In addition, selected molecules (50, 51, 58, 60, 63, 70, 72, 74, 78, 81, 84, and 87) that are representative of the two series of compounds did not show cytotoxicity in vitro when tested against human umbilical vein endothelial cells up to a concentration of 100 μM. The most promising compounds (82 and 84) showed significant IC50 values close to 26 and 19 nM against the chloroquino-sensitive strain 3D7 and 49 and 42 nM against the multi-drug-resistant strain W2. Furthermore, two model compounds (50 and 70) were found to be quite stable over 48 h at pH 7.4 and 5.2. Overall, our preliminary data indicate that this class of structures contains promising candidates for further study.

Hydrophobic Effects on Photochemical and Photophysical Processes: Evidence for Aggregation of Perfluorocarbon in Aqueous-Organic Solvents

The emission spectra and photodimerization of fluorinated alkyl 2-naphthoates (NpFCn) and 9-anthrylmethyl perfluoroalkanoates (AnFCn) in aqueous-organic binary solvents have been investigated.The fluorescence spectra of NpFCn in dimethyl sulfoxide-water (DMSO-H2O) are dominated by excimer emission.Addition of long chain fluorocarbon compounds to the solution results in a reduction in the excimer emission and an enhancement of monomer emission.Selective excitation of the naphthalene moiety in the mixture solution of NpFCn and AnFCn leads to strong emission from AnFCn.Photoirradiation of NpFCn yields a 'cubane-like' photodimer with a relatively high quantum yield.All these observations suggest that hydrophobic interactions force molecules with long fluorocarbon chains to form aggregates in aqueous-organic binary solvents.