35506-89-9Relevant academic research and scientific papers
Dimethyl sulfite a potential agent for methylation
Mouselmani, Rim,Da Silva, Eric,Lemaire, Marc
, p. 8905 - 8910 (2015/11/02)
The synthesis of methylated ether compounds is an important challenge. A pathway for the synthesis of methyl ethers was investigated using dimethyl sulfite (DMSi). Methylation of 1-octanol was carried out in liquid phase upon different heterogeneous organic and inorganic catalysts at 130°C. Aluminium oxide gave the best result with high conversion and moderate selectivity for methyl 1-octyl ether. Reactions in gas phase at higher temperatures (200°C) were also performed. Methyl 1-octyl ether was obtained in a very high level of selectivity up to 98%. Primary and secondary ethers from unsymmetrical alkyl methyl sulfite were also performed by SO2 extrusion.
Synthesis and anti-influenza virus activity of 7-O-alkylated derivatives related to zanamivir
Honda, Takeshi,Masuda, Takeshi,Yoshida, Shuku,Arai, Masami,Kaneko, Satoru,Yamashita, Makoto
, p. 1925 - 1928 (2007/10/03)
A series of 7-alkyl ether derivatives related to zanamivir were synthesized using direct alkylation of the C-7 alcohol of sialic acid. Alkyl ether moiety of less than 12 carbons in length showed low nanomolar inhibitory activity against influenza A virus sialidase. Furthermore, their moiety improved influenza A virus plaque reduction activity compared to zanamivir. However, removal of the 8,9-diol of the 7-O-alkyl derivatives resulted in loss of antiviral potency. This result suggests that 8,9-diol must play an important role in binding with both influenza A and B virus sialidases.
