355117-74-7Relevant articles and documents
Glycosidase inhibitors of gem-diamine 1-N-iminosugars: Structures in media of enzyme assays
Kondo, Ken-Ichiro,Adachi, Hayamitsu,Shitara, Eiki,Kojima, Fukiko,Nishimura, Yoshio
, p. 1091 - 1095 (2007/10/03)
The relationships between structures and inhibitory activities of glycosidase inhibitors of gem-diamine 1-N-iminosugars in media of enzyme assays have been investigated. It has been proved that gem-diamine 1-N-iminosugar smoothly undergoes a structural change to a hydrated ketone or its derivative via a hemiaminal in the media (pH 5.0-6.3), and that the products generated in the media as well as the parent gem-diamine 1-N-iminosugars potently inhibit glycosidases.