35512-52-8Relevant academic research and scientific papers
Synthesis of 5'-((2)H3)-(-)-11-Nor-9-carboxy-Δ9-Tetrahydrocannabinol Methyl Ester Methyl Ether
Tius, Marcus A.,Kannangara, G. S. Kamali
, p. 9173 - 9186 (1992)
A synthesis of 5'-((2)H3)-(-)-11-nor-carboxy-δ9-tetrahydrocannabinol methyl ester methyl ether (4) has been accomplished from α-bromoenone 10.The key steps are the stereocontrolled cyclobutane ring opening of the cuprate adduct 18 and the cyclization of the cyclohexenyl triflate 21 with excess iodotrimethylsilane to produce Δ9-cylohexenyl triflate 22.An efficient, stereospecific synthesis of optically active (-)-11-nor-9-keto-hexahydrocannabinol (8) has also been accomplished.
