3553-63-7

Upstream product

• 7047-12-3 5-(4-Chlorphenyl)-1,2,4-dithiazol-3-on 
• 2521-24-6 4-chlorothiobenzamide 
• 3553-58-0 2-(4-chlorophenyl)thiazole-4,5-dione 
• 101-02-0 triphenyl phosphite 

Downstream Products

• 13187-53-6 2,6-bis-(4-chloro-phenyl)-[1,3,5]thiadiazin-4-one 
• 75444-53-0 5-(4-Chloro-phenyl)-[1,2,4]thiadiazol-3-ol 

Relevant academic research and scientific papers

1,2,4-Dithiazole-5-ones and 5-thiones as efficient sulfurizing agents of phosphorus(iii) compounds - A kinetic comparative study

The sulfurization efficiency of 25 3-substituted-1,2,4-dithiazole-5-ones and 5-thiones towards triphenyl phosphite in acetonitrile, DCM, THF and toluene at 25 °C was evaluated. All the 1,2,4-dithiazoles are much better sulfurizing reagents than commercially available agents (PADS, TETD, Beaucage's reagent). The most efficient sulfurizing agents in all solvents are 3-phenoxy (4), 3-phenylthio (5) and 3-ethoxy-1,2,4-dithiazole-5-one (1) whose reactivity is at least two orders of magnitude higher than that of other 1,2,4-dithiazoles. Contrary to a previous report, the sulfurization with 1 does not yield carbonylsulfide and ethyl cyanate as the additional reaction products but unstable ethoxythiocarbonyl isocyanate which has been trapped with 4-methoxyaniline. Similar trapping experiments have proven that the site of attack is at the sulfur adjacent to the CO group for compounds 4 and 5. The reaction pathway involves rate-limiting initial nucleophilic attack of the phosphorus at sulfur followed by decomposition of the phosphonium intermediate to the corresponding phosphorothioate and isocyanate/isothiocyanate species. The existence of the phosphonium intermediate during sulfurization of triphenyl phosphine with 3-phenyl-1,2,4-dithiazole-5-thione (7a) was proven using kinetic studies. From the Hammett and Bronsted correlations and from other kinetic measurements it was concluded that the transition-state structure is almost apolar for the most reactive 1,2,4-dithiazoles whereas a polar structure resembling a zwitter-ionic intermediate may be more appropriate for the least reactive 1,2,4-dithiazoles. The extent of P-S bond formation and S-S bond cleavage is very similar in all reaction series but it gradually decreases with the reactivity of the 1,2,4-dithiazole derivatives.

Facile synthesis of 2-azaazulenes from thiobenzoyl isocyanates using trimethylsilyldiazomethane

The reaction of trimethylsilyldiazomethane with thiobenzoyl isocyanates, in situ generated from thiazole-4,5-diones, yielded diazoketones, which were converted into 2-azaazulenes by the intramolecular Buchner reaction.

Thioacyl Isocyanates, XII. Preparation and Comparison of Aliphatic, Aromatic, and Heteroaromatic Compounds

Many 1,2,4-dithiazol-3-ones (2), especially with aliphatic and heterocyclic substituents, and some thiazoline-4,5-diones (3) were synthesized from thioamides (1).Extrusion of sulfur or carbon monoxide, respectively, afforded the thioacyl isocyanates 5.Rea