35536-53-9

Usage

Uses

Used in Pharmaceutical Industry:
11-Deoxy Prostaglandin E2 is used as a bronchoconstrictor for the purpose of studying and treating respiratory conditions. Its potent bronchoconstricting properties make it a valuable tool in understanding the mechanisms behind respiratory diseases and developing targeted therapies.
Used in Research and Development:
In the field of research and development, 11-deoxy Prostaglandin E2 is utilized as a research compound to investigate the effects of bronchoconstriction on the respiratory system. This helps scientists gain insights into the underlying causes of various respiratory disorders and develop new treatment strategies.
Used in Diagnostic Procedures:
11-Deoxy Prostaglandin E2 can be employed in diagnostic procedures to assess the responsiveness of the respiratory tract smooth muscle. This can aid in the identification of patients with specific respiratory conditions and guide appropriate treatment plans.
Used in Drug Development:
As a powerful bronchoconstrictor, 11-deoxy Prostaglandin E2 may be used in the development of new drugs targeting respiratory diseases. By understanding its mechanism of action, researchers can potentially design medications that counteract or modulate its effects, leading to more effective treatments for patients with respiratory conditions.

Upstream product

• 42186-61-8 5-(Triphenyl-λ⁵-phosphanylidene)-pentanoic acid anion 
• 90157-69-0 [(6R,7R)-7-((E)-(S)-3-Hydroxy-oct-1-enyl)-1,4-dioxa-spiro[4.4]non-6-yl]-acetaldehyde 
• 78507-23-0 {(3aR,4R,6aS)-4-[(E)-3-(tert-Butyl-dimethyl-silanyloxy)-oct-1-enyl]-hexahydro-cyclopenta[b]furan-2-yl}-methanol 
• 78507-23-0 6β-<(E)-3-oct-1-enyl>-3α-hydroxymethyl-cis-α-2-oxabicyclo<3.3.0>octane 
• 78507-23-0 6β-<(E)-3-oct-1-enyl>-3β-hydroxymethyl-cis-α-2-oxabicyclo<3.3.0>octane 
• 78507-24-1 6β-<(E)-3-oct-1-enyl>-cis-α-2-oxabicyclo<3.3.0>octane-3-one 
• 35120-22-0 (Z)-7-[(1S,2R)-2-((E)-(S)-3-Hydroxy-oct-1-enyl)-5-oxo-cyclopentyl]-hept-5-enoic acid methyl ester 
• 65627-35-2 rac-1R*,3S*,5S*,6S*,1'E-3-hydroxy-6-endo-(3'-hydroxy-2'-octenyl)-2-oxabicyclo<3.3.0>octane 
• 34896-05-4 γ-lactone of 5α-hydroxy-2β-(3-oxo-1-trans-octenyl)-1α-cyclopentaneacetic acid 
• 99097-85-5 15-tert-butyldimethylsilyl ether of rac-8R*,9S*,12S*,15R*-11-deoxyprostaglandin-E₂ methyl ester 
• 87692-31-7 15-tert-butyldimethylsilyl ether of rac-8R*,9S*,12S*,15R*-11-deoxyprostaglandin-F_2α methyl ester 
• 81007-56-9 rac-1R*,3S*,5S*,6S*,1'S*,2'E-3-exo-methoxy-6-endo-(3'-acetoxy-2'-octenyl)-2-oxabicyclo<3.3.0>octane 
• 110217-02-2 rac-1R*,3S*,5S*,6S*,1'S*,2'E-3-exo-methoxy-6-endo-(1'-acetoxy-2'-octenyl)-2-oxabicyclo<3.3.0>octane 
• 110217-01-1 rac-1R*,3S*,5S*,6S*,1'S*,2'E-3-exo-methoxy-6-endo-(1'-hydroxy-2'-octenyl)-2-oxabicyclo<3.3.0>octane 

Relevant academic research and scientific papers

STEREOCONVERGENT METHOD FOR CONSTRUCTION OF THE ω-SIDE CHAIN OF PROSTAGLANDINS WITH 1-HEPTYNE AS SYNTHON

A stereoconvergent method for the construction of the ω-chain by condensation with 1-heptyne, leading to the epimeric acetylenic alcohols, and by conversion of both epimers into the final product by similar schemes is described for the case of the synthesis of rac-11-deoxy-prostaglandin-E2 form the known prostaglandin synthon 3-methoxy-6-endo-formyl-2-oxabicyclooctane.Stereoconvergence is achieved by the use of the stereochemical relationships govering the isomerization of substituted acetates of cis- and trans-allyl alcohols catalyzed by palladium salts.

A new and unusually flexible route to cyclopentanoids synthesis of sarkomycin and prostaglandins

Combination of the dianion of dialky 3-hexenedioate and β-bromopropionate leads directly to a 2,3-disubstituted cyclopentanone, which can be transformed to a variety of primary prostaglandins and sarkomycin.

Organocuprate Conjugate-addition-Enolate-alkylation Reactions: A New Synthesis of 11-Deoxyprostaglandins

A short synthesis of a key 11-deoxyprostaglandin precursor, 6β--cis-α-2-oxabicyclooctan-3-one (11), is reported.Important reactions in the synthesis include preparation of 2α-allyl-3β-oct-1-enyl>cyclopentanone (4) by an organocuprate conjugate-addition-enolate-alkylation reaction, regiospecific epoxidation-cyclisation of the alcohol (7) to give 6β-oct-1-enil>-3-hydroxymethyl-cis-α-2-oxabicyclooctane (9), and oxidative degradation of (9) with manganese dioxide to give 6β-oct-1-enyl)-cis-α-2-oxabicyclooctan-3-one (10).

Novel compounds of the 11-deoxyprostaglandin E3, R3α, and F3β series

This disclosure describes compounds of the 11-deoxyprostaglandin E2, F2α, F2β, E3, F3α, and F3β series having bronchodilator activity.