355381-83-8

Basic information

• Product Name: (3,4-DIMETHOXY-BENZYL)-[2-(4-FLUORO-PHENYL)-ETHYL]-AMINE
• Synonyms: CHEMBRDG-BB 5550280;(3,4-DIMETHOXY-BENZYL)-[2-(4-FLUORO-PHENYL)-ETHYL]-AMINE;(3,4-dimethoxybenzyl)[2-(4-fluorophenyl)ethyl]amine(SALTDATA: HCl);N-(3,4-dimethoxybenzyl)-2-(4-fluorophenyl)ethanamine
• CAS NO: 355381-83-8
• Molecular Formula: C₁₇H₂₀FNO₂
• Molecular Weight: 289.34
• Mol File: 355381-83-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 398.3°C at 760 mmHg
• Flash Point: 194.7°C
• Appearance: /
• Density: 1.11g/cm³
• Vapor Pressure: 1.49E-06mmHg at 25°C
• Refractive Index: 1.541
• CAS DataBase Reference: (3,4-DIMETHOXY-BENZYL)-[2-(4-FLUORO-PHENYL)-ETHYL]-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (3,4-DIMETHOXY-BENZYL)-[2-(4-FLUORO-PHENYL)-ETHYL]-AMINE(355381-83-8)
• EPA Substance Registry System: (3,4-DIMETHOXY-BENZYL)-[2-(4-FLUORO-PHENYL)-ETHYL]-AMINE(355381-83-8)

Safety Data

• Hazardous Substances Data: 355381-83-8(Hazardous Substances Data)

Usage

Description

(3,4-DIMETHOXY-BENZYL)-[2-(4-FLUORO-PHENYL)-ETHYL]-AMINE is a complex organic compound that features a benzyl group with two dimethoxy substituents and an amine group attached to a 2-(4-fluoro-phenyl)ethyl group. This molecule contains aromatic rings and amine functional groups, which may confer properties akin to other compounds with similar chemical structures. Its unique structural and electronic characteristics suggest potential applications in pharmaceutical research, organic synthesis, and various industrial fields.

Uses

Used in Pharmaceutical Research:
(3,4-DIMETHOXY-BENZYL)-[2-(4-FLUORO-PHENYL)-ETHYL]-AMINE is used as a chemical intermediate for the development of new pharmaceuticals, leveraging its structural and electronic properties to create novel drug candidates.
Used in Organic Synthesis:
In the field of organic synthesis, (3,4-DIMETHOXY-BENZYL)-[2-(4-FLUORO-PHENYL)-ETHYL]-AMINE serves as a building block or reactant in the synthesis of more complex organic molecules, contributing to the creation of advanced materials and specialty chemicals.
Used in Industrial Applications:
(3,4-DIMETHOXY-BENZYL)-[2-(4-FLUORO-PHENYL)-ETHYL]-AMINE is utilized in various industrial applications, potentially including the development of new materials, chemical processes, or as a component in formulations that require its specific chemical attributes.

InChI:InChI=1/C17H20FNO2/c1-20-16-8-5-14(11-17(16)21-2)12-19-10-9-13-3-6-15(18)7-4-13/h3-8,11,19H,9-10,12H2,1-2H3

Upstream product

• 1583-88-6 4-fluoro-2-phenethylamine 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 1338239-81-8 C₁₇H₁₈FNO₂ 

Downstream Products

• 1338240-20-2 CHO₂^(1-)*C₁₉H₁₉FNO₂⁽¹⁺⁾ 

Relevant articles and documents

Synthesis, structure-activity relationship and in vitro biological evaluation of N-arylethyl isoquinoline derivatives as Coxsackievirus B3 inhibitors

Currently, there is no approved antiviral drug for the infection caused by enteroviruses. A series of novel N-arylethyl isoquinoline derivatives defined with substituents on the ring A and C were designed, synthesized and evaluated in vitro for their activities against Coxsackievirus B3 (CVB3). The primary structure-activity relationship revealed that substituents on the ring A were not beneficial for the activity. Among these analogs synthesized, compound 7f bearing a methylenedioxy at the R4 and R5 positions afforded an anti-CVB3 activity and a reasonable selectivity index (SI = 26.8); furthermore, 7f exhibited a moderate activity against enterovirus 71 (EV71) with SI value of 9.0. Thus it has been selected as an anti-enteroviral lead compound for further investigation.