355386-94-6

Usage

Uses

Used in Pharmaceutical Research:
Quinoline-5-boronic acid is utilized as a key intermediate in the synthesis of various pharmaceutical compounds. Its ability to form coordination complexes allows for the development of new drugs with improved properties and therapeutic effects.
Used in Organic Synthesis:
As a building block in organic synthesis, Quinoline-5-boronic acid is employed for the creation of complex organic molecules. Its reactivity and compatibility with other organic molecules facilitate the synthesis of a wide range of chemical products.
Used in Agrochemical Development:
Quinoline-5-boronic acid is also used in the development of new agrochemicals, where its coordination complex formation capability can lead to the creation of novel compounds with enhanced pesticidal or herbicidal properties.
Used in Electronic Materials Production:
Quinoline-5-boronic acid finds application in the production of OLEDs (organic light-emitting diodes) and other electronic materials. Its versatile properties and compatibility with various organic molecules make it suitable for use in advanced electronic devices and technologies.

InChI:InChI=1/C9H8BNO2/c12-10(13)8-4-1-5-9-7(8)3-2-6-11-9/h1-6,12-13H

Upstream product

• 4964-71-0 5-bromoquinoline 
• 121-43-7 Trimethyl borate 
• 5419-55-6 Triisopropyl borate 
• 7732-18-5 water 

Downstream Products

• 1021918-21-7 (3-amino-6-(5-quinolinyl)pyrazin-2-yl)[(4-methoxyphenyl)methyl]amine 
• 1021919-56-1 3-nitro-N-(1-phenylethyl)-6-(quinolin-5-yl)pyridin-2-amine 
• 1021920-42-2 (R)-1-(1-phenylethyl)-6-(quinolin-5-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one 
• 1021920-43-3 1-(1-phenylethyl)-6-(quinolin-5-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one 
• 1021919-71-0 ((1R)-1-phenylethyl)(5-nitro-2-(5-quinolyl)(4-pyridyl))amine 
• 1411985-86-8 5-(trifluoro-λ4-boraneyl)quinoline potassium salt 
• 1062368-49-3 ML₃₄₇ 
• 16675-62-0 methyl quinoline-5-carboxylate 

Relevant academic research and scientific papers

Electrochemical Synthesis of Biaryls via Oxidative Intramolecular Coupling of Tetra(hetero)arylborates

We report herein versatile, transition metal-free and additive-free (hetero)aryl-aryl coupling reactions promoted by the oxidative electrocoupling of unsymmetrical tetra(hetero)arylborates (TABs) prepared from ligand-exchange reactions on potassium trifluoroarylborates. Exploiting the power of electrochemical oxidations, this method complements the existing organoboron toolbox. We demonstrate the broad scope, scalability, and robustness of this unconventional catalyst-free transformation, leading to functionalized biaryls and ultimately furnishing drug-like small molecules, as well as late stage derivatization of natural compounds. In addition, the observed selectivity of the oxidative coupling reaction is related to the electronic structure of the TABs through quantum-chemical calculations and experimental investigations.

Composite taken as URAT 1 inhibitor

The invention provides a series of composite with a formula (I), wherein n is selected from 1, 2 or 3, X is selected from O or S, Q is selected from C or N, and R is selected from H, halogen or -C1-6.The composite can be used as the URAT 1 inhibitor and can be used for treating hyperuricemia and gout.

Nickel-catalyzed borylation of halides and pseudohalides with tetrahydroxydiboron [B2(OH)4]

Arylboronic acids are gaining increased importance as reagents and target structures in a variety of useful applications. Recently, the palladium-catalyzed synthesis of arylboronic acids employing the atom-economical tetrahydroxydiboron (BBA) reagent has been reported. The high cost associated with palladium, combined with several limitations of both palladium- and copper-catalyzed processes, prompted us to develop an alternative method. Thus, the nickel-catalyzed borylation of aryl and heteroaryl halides and pseudohalides using tetrahydroxydiboron (BBA) has been formulated. The reaction proved to be widely functional group tolerant and applicable to a number of heterocyclic systems. To the best of our knowledge, the examples presented here represent the only effective Ni-catalyzed Miyaura borylations conducted at room temperature.

Synthesis of quinolyl- and isoquinolyl heteroarylamines using palladium catalyzed suzuki cross-coupling reaction

Quinolyl- and isoquinolylboronic acids are prepared from 5-bromoquinoline and 5-bromoisoquinoline, respectively, via halogen-metal exchange. Suzuki cross-coupling of these compounds with haloheteroarylamine leading to the corresponding heteroarylamine derivatives is described.{A figure is presented}.