35541-78-7Relevant academic research and scientific papers
The diol compound is a polymer and method for manufacturing them
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Paragraph 0170-0176, (2021/10/13)
[A] may be chemically synthesized, derived from a high molecular weight resin can be prepared by a novel diol compound having a backbone 3HB, this diol compound (polymer) resin containing a polymerization component, and method for manufacturing the same i
Synthesis and evaluation of novel potent TSPO PET ligands with 2-phenylpyrazolo[1,5-a]pyrimidin-3-yl acetamide
Hieu Tran, Van,Park, Hyunjun,Park, Jaekyung,Kwon, Young-Do,Kang, Shinwoo,Ho Jung, Jae,Chang, Keun-A,Chul Lee, Byung,Lee, Sang-Yoon,Kang, Soosung,Kim, Hee-Kwon
, p. 4069 - 4080 (2019/08/26)
Translocator protein (TSPO) expression is closely related with neuroinflammation and neuronal damage which might cause several central nervous system diseases. Herein, a series of TSPO ligands (11a–c and 13a–d) with a 2-phenylpyrazolo[1,5-a]pyrimidin-3-yl acetamide structure were prepared and evaluated via an in vitro binding assay. Most of the novel ligands exhibited a nano-molar affinity for TSPO, which was better than that of DPA-714. Particularly, 11a exhibited a subnano-molar TSPO binding affinity with suitable lipophilicity for in vivo brain studies. After radiolabeling with fluorine-18, [18F]11a was used for a dynamic positron emission tomography (PET) study in a rat LPS-induced neuroinflammation model; the inflammatory lesion was clearly visualized with a superior target-to-background ratio compared to [18F]DPA-714. An immunohistochemical examination of the dissected brains confirmed that the uptake location of [18F]11a in the PET study was consistent with a positively activated microglia region. This study proved that [18F]11a could be employed as a potential PET tracer for detecting neuroinflammation and could give possibility for diagnosis of other diseases, such as cancers related with TSPO expression.
Hydrogenolysis of Small Cycloalkanes, XV. - Hydrogenation of Dispirodeca-4,9-diene
Kiwus, Regina,Schwarz, Wolfgang,Rossnagel, Ingrid,Musso, Hans
, p. 435 - 438 (2007/10/02)
On hydrogenation of the title compound 1 with Pd/C 1,4-diethylbenzene (2) is formed in 95percent yield, furthermore 1percent of cis- and 2percent of trans-1,4-diethylcyclohexane (3 and 4) as well as 2percent of 6-ethylspirooctane (15) are found.With Pt/C the intermediates 7, 12, 13, and 14 and up to 45percent of dispirodecane (17) are identified. 17 is hydrogenated with PtO2 in acetic acid to form 1,1,4,4-tetramethylcyclohexane (19).
