35546-47-5Relevant academic research and scientific papers
Syntheses, in vitro α-amylase and α-glucosidase dual inhibitory activities of 4-amino-1,2,4-triazole derivatives their molecular docking and kinetic studies
Aboaba, Sherifat A.,Chigurupati, Sridevi,Hameed, Shehryar,Kannan Maharajan, Mari,Kanwal,Mohammed Khan, Khalid.,Perveen, Shahnaz,Shamim, Shahbaz,Taha, Muhammad,Ur Rehman, Ashfaq,Wadood, Abdul,Yeye, Emmanuel Oloruntoba
, (2020/04/23)
Thirty-three 4-amino-1,2,4-triazole derivatives 1–33 were synthesized by reacting 4-amino-1,2,4-triazole with a variety of benzaldehydes. The synthetic molecules were characterized via 1H NMR and EI-MS spectroscopic techniques and evaluated for
An Efficient Synthesis and Antibacterial Activity of Some Novel 2-Azetidinone Derivatives of 4H-1,2,4-Triazoles Under Mild Conditions
Khan, Takallum,Yadav, Ritu,Gound, Surendra Singh
supporting information, p. 1042 - 1047 (2018/02/23)
We have synthesized the novel 2-azetidinone derivatives by using Schiff bases of 1,2,4-triazoles via a single step protocol. We used DABCO as a good homogenous, ecofriendly, highly reactive, easy to handle, and nontoxic catalyst. In?DABCO catalyzed synthesis of active 2-oxo-azetidine, a highly electrophilic ketene intermediate can react with weakly nucleophilic (N═CH) linkage, which is used as the precursor for the cycloaddition reaction to deliver the desired products in excellent yields with protic solvents. In addition, the DABCO as an economically viable and readily available catalyst is soluble in almost all solvents and their salts easily filtered off from the reaction medium. Moreover, this new synthetic protocol features high conversion in green solvents and a straightforward procedure.
