35554-75-7Relevant articles and documents
Novel N-substituted indole Schiff bases as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase enzymes: Synthesis, biological activities in?vitro and docking study
Lamie, Phoebe F.,Ali, Waleed A.M.,Bazgier, Vaclav,Rárová, Lucie
, p. 803 - 813 (2016)
Two new series of N-substituted indole derivatives 4a–l and 5a–h were synthesized. Their chemical structures were confirmed using spectroscopic tools including IR,1H NMR,13C NMR mass spectroscopy and elemental analyses. The results showed no significant cytotoxic activity on either cancer or normal human cells. Anti-inflammatory activity for all target compounds was evaluated in?vitro. Compounds 5a–h were found to have better anti-inflammatory activity than 4a–l. The inhibitory activity of COX-2 and 5-LOX were tested for 5a–h. Three compounds, 5c, 5d and 5f showed excellent COX-2 inhibitory activity with IC50ranging from 0.98 to 1.23?μM compared to the reference celecoxib (1.54?μM). These compounds had a reasonable selectivity index between 7.03 and 8.05. Additionally, p-methylbenzoyl derivative 5g (IC50?=?5.78?μM) had superior 5-LOX inhibitory activity, higher than quercetin. 5e was close to quercetin in its LOX inhibitory activity. Compounds 5a–h were docked inside the active site of COX-2 and 5-LOX enzymes.
