35562-24-4Relevant articles and documents
Development of a Scalable Synthetic Route to BMS-986251. Part 1: Synthesis of the Cyclohexane Dicarboxylate Fragment
Coombs, John R.,Eastgate, Martin D.,Gallagher, William P.,Gangu, Aravind S.,Gonzalez-Bobes, Francisco,Joe, Candice L.,Kalidindi, Srinivas,Kopp, Nathaniel,Kuppusamy, Sankar,Mudryk, Boguslaw,Nagappan, Vedhachalam,Palani, Senthil,Ponnusamy, Muthukrishnan,Rupasinghe, Sanjeewa,Tendulkar, Shankar,Vaidyanathan, Rajappa,Venu, Alla,Vinodini, Arun
, p. 1547 - 1555 (2021)
The cyclohexane dicarboxylate unit of BMS-986251 (1), a potent and efficacious RORγt inverse agonist, was synthesized starting from Hagemann's ester in seven chemical transformations with five isolated intermediates. The synthesis involved an enzymatic ki
Organocatalytic cascade reactions based on push-pull dienamine platform: Synthesis of highly substituted anilines
Ramachary, Dhevalapally B.,Ramakumar, Kinthada,Narayana, Vidadala V.
, p. 1458 - 1463 (2007/10/03)
(Chemical Equation Presented) A practical and novel one-pot organocatalytic selective process for the cascade synthesis of highly substituted o-hydroxydiary lamines and o-pyrrolidin-1-yldiarylamines is reported. Direct combination of amine-catalyzed cascade Knoevenagel/Michael/aldol condensation/decarboxylation and cascade enamine amination/isoaromatization of alkyl acetoacetates, aldehydes, and nitrosoarenes furnished the highly functionalized anilines with high yields.