35562-24-4Relevant academic research and scientific papers
Development of a Scalable Synthetic Route to BMS-986251. Part 1: Synthesis of the Cyclohexane Dicarboxylate Fragment
Coombs, John R.,Eastgate, Martin D.,Gallagher, William P.,Gangu, Aravind S.,Gonzalez-Bobes, Francisco,Joe, Candice L.,Kalidindi, Srinivas,Kopp, Nathaniel,Kuppusamy, Sankar,Mudryk, Boguslaw,Nagappan, Vedhachalam,Palani, Senthil,Ponnusamy, Muthukrishnan,Rupasinghe, Sanjeewa,Tendulkar, Shankar,Vaidyanathan, Rajappa,Venu, Alla,Vinodini, Arun
, p. 1547 - 1555 (2021)
The cyclohexane dicarboxylate unit of BMS-986251 (1), a potent and efficacious RORγt inverse agonist, was synthesized starting from Hagemann's ester in seven chemical transformations with five isolated intermediates. The synthesis involved an enzymatic ki
High-yielding synthesis of Nefopam analogues (functionalized benzoxazocines) by sequential one-pot cascade operations
Ramachary, Dhevalapally B.,Narayana, Vidadala V.,Prasad, M. Shiva,Ramakumar, Kinthada
body text, p. 3372 - 3378 (2010/01/06)
An efficient amine-/ruthenium-catalyzed three-step process for the synthesis of Nefopam analogues was achieved through combinations of cascade enamine amination/iso-aromatization/allylation and diene or enyne metathesis as key steps starting from functionalized Hagemann's esters. In this communication, we discovered the application of ruthenium-catalysis on olefins containing free amines without in situ formation of salts.
Organocatalytic cascade reactions based on push-pull dienamine platform: Synthesis of highly substituted anilines
Ramachary, Dhevalapally B.,Ramakumar, Kinthada,Narayana, Vidadala V.
, p. 1458 - 1463 (2007/10/03)
(Chemical Equation Presented) A practical and novel one-pot organocatalytic selective process for the cascade synthesis of highly substituted o-hydroxydiary lamines and o-pyrrolidin-1-yldiarylamines is reported. Direct combination of amine-catalyzed cascade Knoevenagel/Michael/aldol condensation/decarboxylation and cascade enamine amination/isoaromatization of alkyl acetoacetates, aldehydes, and nitrosoarenes furnished the highly functionalized anilines with high yields.
