35564-19-3

Basic information

• Product Name: 3,5-BIS(TRIFLUOROMETHYL)FLUOROBENZENE
• Synonyms: 3,5-BIS(TRIFLUOROMETHYL)FLUOROBENZENE;Bis-3,5-(Trifluoromethyl)Fluorobenzene95%;3,5-Bis(trifluoromethyl)fluorobenzene 98%;3,5-Bis(trifluoromethyl)fluorobenzene98%;1,3-Bis(trifluoromethyl)-5-fluorobenzene 98%;alpha,alpha,alpha,alpha',alpha',alpha',5-Heptafluoro-m-xylene;1-Fluoro-3,5-bis(trifluoroMethyl)benzene;1,3-Bis(trifluoromethyl)-5-fluorobenzene98%
• CAS NO: 35564-19-3
• Molecular Formula: C₈H₃F₇
• Molecular Weight: 232.1
• EINECS: 206-591-3
• Mol File: 35564-19-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 99.8 °C at 760 mmHg
• Flash Point: 17.8 °C
• Appearance: /
• Density: 1.444 g/cm³
• Vapor Pressure: 43.4mmHg at 25°C
• Refractive Index: 1.368
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3,5-BIS(TRIFLUOROMETHYL)FLUOROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-BIS(TRIFLUOROMETHYL)FLUOROBENZENE(35564-19-3)
• EPA Substance Registry System: 3,5-BIS(TRIFLUOROMETHYL)FLUOROBENZENE(35564-19-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 35564-19-3(Hazardous Substances Data)

Usage

General Description

3,5-Bis(trifluoromethyl)fluorobenzene is a chemical compound with the molecular formula C8H3F6. It is a colorless liquid at room temperature and is insoluble in water. 3,5-BIS(TRIFLUOROMETHYL)FLUOROBENZENE is commonly used as a solvent in organic chemical reactions and as a reagent in the synthesis of pharmaceuticals and other organic compounds. It is also a useful building block in the production of specialty chemicals and materials. 3,5-Bis(trifluoromethyl)fluorobenzene is known for its strong and stable chemical properties, making it a valuable tool in the field of organic chemistry. However, it should be handled with care due to its potential health and environmental hazards.

InChI:InChI=1/C8H3F7/c9-6-2-4(7(10,11)12)1-5(3-6)8(13,14)15/h1-3H

Upstream product

• 328-70-1 3,6-bis(trifluoromethyl)bromobenzene 
• 881-99-2 1,3-bis-trichloromethyl-benzene 
• 328-74-5 3,5-Bis-(trifluoromethyl)aniline 
• 328-75-6 1-nitro-3,5-bis(trifluoromethyl)benzene 

Downstream Products

• 155019-79-7 2,2',2''-tris<(3,5-bis(trifluoromethyl)phenyl)amino>triethylamine 

Relevant articles and documents

Copper-Mediated Fluorination of Aryl Trisiloxanes with Nucleophilic Fluoride

A method for the nucleophilic fluorination of heptamethyl aryl trisiloxanes to form fluoroarenes is reported. The reaction proceeds in the presence of Cu(OTf)2 and KHF2 as the fluoride source under mild conditions for a broad range of heptamethyltrisiloxyarenes with high functional group tolerance. The combination of this method with the silylation of aryl C?H bonds enables the regioselective fluorination of non-activated arenes controlled by steric effects following a two-step protocol.

Anhydrous tetrabutylammonium fluoride

Tetrabutylammonium fluoride (TBAF) is prepared at low temperature by nucleophilic aromatic substitution of hexafluorobenzene with tetrabutylammonium cyanide. Adventitious water is scavenged during this synthesis by the generated hexacyanobenzene, which readily adds water under basic conditions. Contrary to expectations, TBAF is stable to Hofmann elimination in polar aprotic solvents under anhydrous conditions. Added hydroxylic solvents are shown to catalyze the decomposition of TBAF and to catalyze proton exchange with DMSO. The synthetic utility of this salt is described briefly. Copyright